Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1980-08-28
1982-11-23
Schain, Howard E.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
424 85, 424101, C07G 700
Patent
active
043604579
ABSTRACT:
The present invention is directed to an S-sulfonated immunoglobulin composition comprising an S-sulfonated immunoglobulin and as an aggregation preventing agent or an aggregate dissociating agent, therefor, about 1 to about 600% by weight, based on the weight of the S-sulfonated immunoglobulin, of a water-soluble acid addition salt of a basic nitrogen-containing organic compound containing one or more basic nitrogen atoms in the molecule and optionally carboxyl groups smaller in number than the basic nitrogen atoms and having a pKb at 25.degree. C. of not more than 7.
There is also provided a process for producing an S-sulfonated immunoglobulin composition having a high monomer content, which comprises contacting an S-sulfonated immunoglobulin in aqueous solution with about 1 to about 600% by weight, based on the weight of the S-sulfonated immunoglobulin, of the water-soluble acid addition salt, or reacting an immunoglobulin in aqueous solution with a compound capable of yielding a sulfite ion in water and an oxidizing agent in the presence of about 1 to about 600% by weight, based on the immunoglobulin, of the water-soluble acid addition salt.
REFERENCES:
patent: 4059571 (1977-11-01), Tomibe et al.
patent: 4118379 (1978-10-01), Schmidtberger
patent: 4160763 (1979-07-01), Muller
Acta Chemica Scandinavica 22 (1968), pp. 490-496, Hansson.
Fukumoto Yuji
Ono Syoji
Yoshida Tsunemasa
Schain Howard E.
Teijin Limited
The Chemo-Sero-Therapeutic Research Institute
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