Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Calcitonin; related peptides
Patent
1989-06-07
1992-10-06
Lee, Lester L.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Calcitonin; related peptides
530345, A61K 3702, A61K 3730, C07K 500, C07K 700
Patent
active
051533081
ABSTRACT:
Calcitonin derivatives wherein at least one of the first cysteine residue and the seventh cysteine residue is S-sulfonated; processes for the production of the calcitonin derivatives comprising the steps of reacting a calcitonin with a sulfite anion or both a sulfite anion and an oxidizing agent to form the S-sulfonated derivative, and recovering the sulfonated calcitonin derivative; a pharmaceutical composition comprising the S-sulfonated calcitonin derivative; and a method of treating a patient having a disease wherein a decrease of a serum calcium level is desired, by administering the S-sulfonated calcitonin derivative to the patient.
REFERENCES:
patent: 4212795 (1980-07-01), Hughes et al.
patent: 4658014 (1987-04-01), Kempe
patent: 4720483 (1988-01-01), Jansz et al.
patent: 4758550 (1988-07-01), Cardinaux e al.
Haruaki Yajima et al., Tetrahedron vol. 44, No. 3, 805-819, 1988.
Kamimura Takashi
Masuda Kenichi
Sugiyama Takashi
Suzuki Yoji
Davenport A. M.
Lee Lester L.
Teijin Limited
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