S-oxide and S,S-dioxide tetrahydrothiopyran phenyloxazolidinones

Details S-oxide and S,S-dioxide tetrahydrothiopyran phenyloxazolidinones S-oxide and S,S-dioxide tetrahydrothiopyran phenyloxazolidinones

1998-11-20

2000-07-04

Lambkin, Deborah C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548232, A61K 3142, C07D26304

Patent

active

060839678

ABSTRACT:
The present invention provides compounds of formula I and formula II useful as antimicrobial agents wherein R.sub.1 is methyl, ethyl, cyclopropyl, or dichloromethyl; R.sub.2 and R.sub.3 are independently hydrogen or fluoro; R.sub.4 is ethyl or dichloromethyl. The invention also relates to a novel assay for determining the inhibitory activity of oxazolidinones to human monoamine oxidase.

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P. Flaherty, et al., J. Med. Chem, 39:4756-4761 (1996).
JJP Zhou, et al., Analytical Biochem., 234:9-12 (1996).

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