Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-10-06
1996-07-16
Higel, Floyd D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514255, 514400, 514417, 514423, 514550, 514562, 544 12, 544 13, 544287, 544288, 544289, 544349, 544354, 544355, 546225, 546226, 546242, 546323, 546326, 546328, 548200, 548215, 548413, 548553, 548537, 548952, 548953, 548181, 558488, 560 16, 560125, 560147, 562426, 564154, A61K 3150, A61K 31495, A61K 31415, A61K 3140, A61K 3122, A61K 31195, C07D23972, C07D21130
Patent
active
055367232
ABSTRACT:
The invention relates to novel S-nitroso derivatives of ACE inhibitors and to pharmaceutical compositions comprising the S-nitrosothiol derivatives of the invention together with a pharmaceutically acceptable carrier.
The invention also relates to methods for treating various pathophysiological conditions including acute myocardial infarction, left ventricular dysfunction without overt heart failure, hypertension, pulmonary hypertension, congestive heart failure, angina pectoris, vascular thrombosis, Raynauds syndrome, scleroderma, toxemia of pregnancy, acute renal failure, diabetic nephropathy, and renal artery stenosis, and to methods of inhibiting ACE and effecting vasodilation comprising administering the S-nitrosothiol derivatives of the ACE inhibitors of the invention to an animal.
REFERENCES:
patent: 4046889 (1977-09-01), Ondetti et al
patent: 4052511 (1977-10-01), Cushman et al.
patent: 4053651 (1977-10-01), Ondetti et al.
patent: 4113715 (1978-09-01), Ondetti et al
patent: 4129571 (1978-12-01), Ondetti et al.
patent: 4154840 (1979-05-01), Ondetti et al.
patent: 4154960 (1979-05-01), Ondetti et al.
patent: 4447419 (1984-05-01), Quadro
patent: 4461896 (1984-07-01), Portlock
patent: 4568675 (1986-02-01), Bush et al.
patent: 4585758 (1986-04-01), Huang
patent: 4626545 (1986-12-01), Taub
patent: 4681866 (1987-07-01), Hagwitz
patent: 4692458 (1987-09-01), Ryan et al.
patent: 4692459 (1987-09-01), Ryan
patent: 4748160 (1988-05-01), Bennion et al.
patent: 5002964 (1991-03-01), Loscalzo et al.
patent: 5025001 (1991-06-01), Loscalzo et al.
patent: 5187183 (1993-02-01), Loscalzo et al.
patent: 5356890 (1994-10-01), Loscalzo et al.
Cushman et al, Biochemistry, vol. 16, pp. 5484 to 5549 (1977).
Drummer et al, Pharmacology, vol. of 1987, pp. 545 to 550.
Horowitz et al, Circulation, vol. 68, pp. 1247 to 1253 (1983).
Ignarro et al, Biochem. Biophys Acta, vol. 631, pp. 221 to 231 (1980).
Kadin, Analytical Profiles of Drug Substances, vol. 11, pp. 79 to 137 (1982).
Lidell et al, Analyst, vol. 84, pp. 188 to 190 (1959).
Loscalzo, J. Clin. Invest., vol. 76, pp. 703 to 708 (1985).
Ondetti, Circulation, vol. 77 (Suppl.), pp. 74 to 78 (1988).
Sieh et al, J. Pharm Sci, vol. 73, pp. 1545 to 1547 (1984).
Van Gilst et al I, J. Cardiovasc. Pharmacol., vol. 9, pp. 254 to 255 (1987).
Van Gilst et al II, Circ. Suppl. II, vol. 78, II-221 (Abstr 1882) (1988).
Cooke John
Loscalzo Joseph
Brigham & Women's Hospital
Herron Charles J.
Higel Floyd D.
Olstein Elliot M.
LandOfFree
S-nitroso derivatives of hydrazinoacetic acids, 1-[(acylthio and does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with S-nitroso derivatives of hydrazinoacetic acids, 1-[(acylthio and, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and S-nitroso derivatives of hydrazinoacetic acids, 1-[(acylthio and will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1784466