S-nitroso derivatives of ace inhibitors and the use thereof

Details S-nitroso derivatives of ace inhibitors and the use thereof S-nitroso derivatives of ace inhibitors and the use thereof

1993-02-04

1994-10-18

Higel, Floyd D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514250, 514354, 544347, 546323, 546326, 546328, 548953, A61K 31395, A61K 31445, A61K 31495, C07D24146, C07D20510

Patent

active

053568907

ABSTRACT:
The invention relates to novel S-nitroso derivatives of ACE inhibitors and to pharmaceutical compositions comprising the S-nitrosothiol derivatives of the invention together with a pharmaceutically acceptable carrier.
The invention also relates to methods for treating various pathophysiological conditions including acute myocardial infarction, left ventricular dysfunction without overt heart failure, hypertension, pulmonary hypertension, congestive heart failure, angina pectoris, vascular thrombosis, Raynauds syndrome, scleroderma, toxemia of pregnancy, acute renal failure, diabetic nephropathy, and renal artery stenosis, and to methods of inhibiting ACE and effecting vasodilation comprising administering the S-nitrosothiol derivatives of the ACE inhibitors of the invention to an animal.

REFERENCES:
patent: 4046889 (1977-09-01), Ondetti et al.
patent: 4052511 (1977-10-01), Cushman et al.
patent: 4053651 (1977-10-01), Ondetti et al.
patent: 4113715 (1978-09-01), Ondetti et al.
patent: 4129571 (1978-12-01), Ondetti et al.
patent: 4154840 (1979-05-01), Ondetti et al.
patent: 4154960 (1979-05-01), Ondetti et al.
patent: 4447419 (1984-05-01), Quadro
patent: 4461896 (1984-07-01), Portlock
patent: 4568675 (1986-02-01), Bush et al.
patent: 4585758 (1986-04-01), Huang
patent: 4626545 (1986-12-01), Taub
patent: 4681866 (1987-07-01), Haugwitz
patent: 4692458 (1987-09-01), Ryan et al.
patent: 4692459 (1987-09-01), Ryan
patent: 4748160 (1988-05-01), Bennion et al.
patent: 5002964 (1991-03-01), Loscalzo et al.
patent: 5025001 (1991-06-01), Loscalzo et al.
patent: 5187183 (1993-02-01), Loscalzo et al.
Loscalzo, J. Clin. Invest, vol. 76, pp. 703-708 (1985).
Kadin, "Analytical Profiles of Drug Substances", vol. 11, pp. 79-137 (1982).
Cushman et al., Biochemistry, vol. 16, pp. 5484-5549 (1977).
Drummer et al., Pharmacology, pp. 545 to 550 (1987).
Horowitz et al., Circulation, vol. 68, pp. 1247-1253 (1983).
Ignarro et al., Biochem. Biophys. ACTA, vol. 631, pp. 221-231 (1980).
Lidell et al., Analyst, vol. 84, pp. 188-190 (1959).
Ondetti, Circulation, 77 (Supp. 1) pp. 74-78 (1988).
Sieh et al., J. Pharm. Sci., vol. 73, pp. 1545-1547 (1984).
Van Gilst et al. I, J. Cardiovasc. Pharmacol., vol. 9, pp. 254-255 (1987).
Van Gilst et al. II, Circ. Suppl. II, vol. 78, II-221 (Abstr 0882) (1988).

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