S-nitroso derivatives of ACE inhibitors and the use thereof

Details S-nitroso derivatives of ACE inhibitors and the use thereof S-nitroso derivatives of ACE inhibitors and the use thereof

1991-06-14

1993-02-16

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514419, 514542, 514550, 514562, 514616, 560 16, 560125, 560147, 562426, 562507, 562557, 562556, 564153, 564154, A61K 31415

Patent

active

051871831

ABSTRACT:
The invention relates to novel S-nitroso derivatives of ACE inhibitors and to pharmaceutical compositions comprising the S-nitrosothiol derivatives of the invention together with a pharmaceutically acceptable carrier.
The invention also relates to methods for treating various pathophysiological conditions including acute myocardial infarction, left ventricular dysfunction without overt heart failure, hypertension, pulmonary hypertension, congestive heart failure, angina pectoris, vascular thrombosis, Raynauds syndrome, scleroderma, toxemia of pregnancy, acute renal failure, diabetic nephropathy, and renal artery stenosis, and to methods of inhibiting ACE and effecting vasodilation comprising administering the S-nitrosothiol derivatives of the ACE inhibitors of the invention to an animal.

REFERENCES:
patent: 4046889 (1977-09-01), Ondetti et al.
patent: 4052511 (1977-10-01), Cushman et al.
patent: 4053651 (1977-10-01), Ondetti et al.
patent: 4113715 (1978-09-01), Ondetti et al.
patent: 4129571 (1978-12-01), Ondetti et al.
patent: 4154840 (1979-05-01), Ondetti et al.
patent: 4154960 (1979-05-01), Ondetti et al.
patent: 4447419 (1984-05-01), Quadro
patent: 4461896 (1984-07-01), Portlock
patent: 4568675 (1986-02-01), Bush et al.
patent: 4585758 (1986-04-01), Huang
patent: 4626545 (1986-12-01), Taub
patent: 4681866 (1987-07-01), Haugwitz
patent: 4692458 (1987-09-01), Ryan et al.
patent: 4692459 (1987-09-01), Ryan
patent: 4748160 (1988-05-01), Bennion et al.
patent: 5002964 (1991-03-01), Loscalzo et al.
patent: 5025001 (1991-06-01), Loscalzo et al.
Loscalzo, J. Clin. Invest, 76, pp. 703-708 (1985).
Kadin, "Analytical Profiles of Drug Substances," 11 p. 79-137 (1982).
Cushman, D. W. et al., Biochemistry 16:5484-5491 (1977).
Drummer, O. H. et al., Pharmacology 545-550 (1987).
Horowitz, J. D. et al. Circulation 68:1247-1253 (1983).
Ignarro, L. J. et al., Biochem, Biophys. Acta 631:221-231.
Lidell, H. et al., Analyst 84:188-190 (1959).
Ondetti, M. A., Circulation 77(Supp. 1) 74-78 (1988).
Sieh, D. H. et al., J. Pharm. Sci. 73:1545-1547 (1984).
van Gilst, W. H. et al., J. Cardiovasc. Pharmacol. 9:254-255 (1987).
van Gilst, W. H. et al., Circ. Suppl. II 78:II-221 (Abstr. 0882) (1988).
International Search Report for the corresponding PCT Application, PCT/US89/02611 filed Jun. 15, 1989, of this application.

Affiliated with

Also associated with

Rating

S-nitroso derivatives of ACE inhibitors and the use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with S-nitroso derivatives of ACE inhibitors and the use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and S-nitroso derivatives of ACE inhibitors and the use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2148234