S-nitroso derivatives of ACE inhibitors and the use thereof

Details S-nitroso derivatives of ACE inhibitors and the use thereof S-nitroso derivatives of ACE inhibitors and the use thereof

1989-03-24

1991-06-18

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

5142232, 514259, 514365, 514412, 514423, 544 12, 544 13, 544287, 544288, 544289, 548201, 548413, 548452, 548533, A61K 31505, A61K 3154, A61K 31425, A61K 3140

Patent

active

050250019

ABSTRACT:
The invention relates to novel S-nitroso derivatives of ACE inhibitors and to pharmaceutical compositions comprising the S-nitrosothiol derivatives of the invention together with a pharmaceutically acceptable carrier.
The invention also relates to methods for treating various pathophysiological conditions including acute myocardial infarction, left ventricular dysfunction without overt heart failure, hypertension, pulmonary hypertension, congestive heart failure, angina pectoris, vascular thrombosis, Raynauds syndrome, scleroderma, toxemia of pregnancy, acute renal failure, diabetic nephropathy, and renal artery stenosis, and to methods of inhibiting ACE and effecting vasodilation comprising administering the S-nitrosothiol derivatives of the ACE inhibitors of the invention to an animal.

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