S-methylcysteine, S-ethylcysteine, and related S-alkylthiols...

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

09879710

ABSTRACT:
A method of inhibiting the actions of S-nitrosothiols and nitric oxide which often occur in conditions such as septic shock, chronic or acute pain syndromes, uterine hypotonus, or certain gastrointestinal disorders. The method involving inhibiting the cellular binding of S-nitrosothiols to their cellular receptors or the signal transduction that would result. This is accomplished by administering an S-alkylthiol such as S-methyl-L-cysteine or S-ethyl-L-cysteine to a patient as an antagonist of S-nitrosothiol.

REFERENCES:
patent: 3892852 (1975-07-01), Joullie et al.
patent: 4772591 (1988-09-01), Meisner
patent: 5552267 (1996-09-01), Stern
patent: 5596011 (1997-01-01), Repine
patent: 5762922 (1998-06-01), Noble
patent: 5780489 (1998-07-01), Brooks
patent: 5827886 (1998-10-01), Hersh
patent: 5906811 (1999-05-01), Hersh
patent: 5972993 (1999-10-01), Ptchelintsev
patent: 6057367 (2000-05-01), Stamler
Chemical Abstracts Registry file Printout of S-Methyl cysteine, 2002.
Chemical Abstracts Registry Printout of S-Methyl Cysteine, 2002.
Volker Burkart et al.; Suppression of nitric oxide toxicity in islet cells by a-tocopherol; 0014-5793/95/59.50 C 1995 Federation of European Biochemical Societies; Germany Federation of European Biochemical Societies: Apr. 6, 1995: pp. 259-263.
Souichi Satoh et al.; NO Donors Stimulate Noradrenaline Release From Rat Hippocampus in a Calmodulin-Dependent Manner in the Presnece of L-Cysteine; Journal of Cellular Physiology 169:87-96 (1996): 1996 Willey-Liss, Inc.: Japan.
Mary Ann De Groote et al.; Homocysteine Antagonism of Nitric Oxide-Related Cytostasis in Salmonelle typhimurium; Science, Apr. 19, 1996; vol. 272; USA.
Zhihui Zhao et al.; Reduced glutathione prevents nitric oxide-induced apoptosis in vascular smooth muscle cells; Biochimica et Biophysica Acts (BBA);1997; pp. 143-152; 0167-4889/97/$17.00 C 1997 Elsevier Science B.V. All rights reserved. PII S0167-4889(97)00093-1; Elsevier; USA.
Neil Hogg, et al.; S-Nitrosoglutathione as a substrate for y-glutamyl transpeptidase; 1997; pp. 477-481; Biochem, J. (1997) 323; Great Britain.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

S-methylcysteine, S-ethylcysteine, and related S-alkylthiols... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with S-methylcysteine, S-ethylcysteine, and related S-alkylthiols..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and S-methylcysteine, S-ethylcysteine, and related S-alkylthiols... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3864126

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.