S-alkylated coenzyme A with effect on polyamine acetylase

Details S-alkylated coenzyme A with effect on polyamine acetylase S-alkylated coenzyme A with effect on polyamine acetylase

1985-04-26

1989-05-02

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 26, 536 28, 536 29, 530331, 544247, C07H 19167, C07H 19207

Patent

active

048269689

ABSTRACT:
The present invention relates to the novel compound N-[2-(S-Coenzyme A) acetyl] sym-norspermidine which electively inhibits the enzyme spermidine/spermine N.sup.1 acetyl transferase thereby aberrating the polyamine biosynthesis pathway. The present compound alone or in combination with other agents can be employed in pharmaceutically acceptable compositions and in convenient dosage forms for use in the treatment of neoplastic diseases, diseases caused by parasitic protozoans, diseases involving deranged cell growth or other related diseases.

REFERENCES:
patent: 2917434 (1959-12-01), Robillant
Erwin, B. G., Persson, L., Pegg, A. E., Biochemistry, vol. 23, pp. 4250-4255, 1984.

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