(S)-Alkyl 3-(thien-2-ylthio)butyrate and analogs and synthesis t

Details (S)-Alkyl 3-(thien-2-ylthio)butyrate and analogs and synthesis t (S)-Alkyl 3-(thien-2-ylthio)butyrate and analogs and synthesis t

1990-04-18

1990-11-06

Siegel, Alan

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D33332

Patent

active

049688146

ABSTRACT:
(S)-Alkyl 3-(thien-2-ylthio)butyrate and analogs are intermediates in the synthesis of the chiral (S,S)-5,6-dihydro-4-ethylamino-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfon amide-7,7-dioxide and analogs thereof, topically effective carbonic anhydrase inhibitors useful in the treatment of ocular hypertension and glaucoma.

REFERENCES:
patent: 4021450 (1977-05-01), Ahrens et al.
patent: 4245107 (1981-01-01), Shibuya et al.
patent: 4797413 (1989-01-01), Baldwin et al.

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