S-(+)-adenosylmethionine and 3'-azido-2', 3'-dideoxy-nucleoside

Details S-(+)-adenosylmethionine and 3'-azido-2', 3'-dideoxy-nucleoside S-(+)-adenosylmethionine and 3'-azido-2', 3'-dideoxy-nucleoside

1997-08-14

2000-09-12

Wilson, James O.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 42, 514 43, 514 46, 514 47, 514 48, 514 49, 514 50, 514 51, 514885, 536 2714, 536 2731, 536 282, A01N 4304

Patent

active

061178497

ABSTRACT:
Molecular Complexes, comprising of S-(+)-adenosylmethionine and 3'-azido-2',3'-dideoxy nucleosides are prepared, and shown to have synergistic inhibitory effects on the replication of human-immunodeficiency virus 1 & 2 in vitro and in vivo, particularly on the reverse transcriptase, and having a high therapeutic index.

REFERENCES:
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patent: 4724232 (1988-02-01), Rideost et al.
patent: 4880782 (1989-11-01), Eckstein et al.
Vogel's Textbook of Practacal Organic Chemistry, Fifth Edition (Wilet,, New York, 1989), pp. 120-131.
ROMPP Chemie Lexikon, Ninth Edition (Georg Thieme Verlag, Stuttgart, 1992, pp. 4055-4056.
Fabianowska-Majewska et al., "Effects of Novel Anti-Viral Adenosine Analogues on the Activity of S-Adenosylhomocysteine Hydrolase from Human Liver", Biochemical Pharmacology 48:5;897-903 (1994).
May, "A Novel Antiviral Strategy for HIV Infection", Medical Hypotheses, 40:93-94 (1993).
Wolfe et al., "S-Adenosyl-L-homocysteine Hydrolase as a Target for Antiviral Chemotherapy", Journal of Medicinal Chemistry, 34:5:1521-1530 (1991).

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