(S)-[6-amino-4-[(1-methyl-2-oxo-2 phenyl-ethyl amino]-5-nitro-2-

Details (S)-[6-amino-4-[(1-methyl-2-oxo-2 phenyl-ethyl amino]-5-nitro-2- (S)-[6-amino-4-[(1-methyl-2-oxo-2 phenyl-ethyl amino]-5-nitro-2-

1989-06-02

1990-08-21

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21376

Patent

active

049507613

ABSTRACT:
The (2S)-(-)-isomer of (5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7-yl)carbamic acid, ethyl ester is significantly more potent than either the (2R)-(+)-isomer or the (R,S)-(.+-.)-racemic mixture in inhibiting mitotic cell division of L1210 leukemia cells.
The compound, pharmaceutical compositions containing the compound, and a method of ameliorating cancer diseases in mammals are disclosed.

REFERENCES:
patent: 3968116 (1976-07-01), Doherty et al.
patent: 4511721 (1985-04-01), Temple, Jr. et al.

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