(S)-2,3-dihydropolyprenyl, monophosphate, and agents for inhibit

Details (S)-2,3-dihydropolyprenyl, monophosphate, and agents for inhibit (S)-2,3-dihydropolyprenyl, monophosphate, and agents for inhibit

1993-06-21

1994-04-26

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

558213, A61K 3166, C07F 9113

Patent

active

053067142

ABSTRACT:
Disclosed are (S)-2,3-dihydropolyprenol of formula (I) ##STR1## wherein m is 7 or 8 and (S)-2,3-dihydropolyprenyl monophosphate of formula (II) ##STR2## wherein m is 7 or 8 as well as pharmaceutically acceptable salts thereof. They are useful as a medicament for inhibiting the growth and/or metastasis of cancers.

REFERENCES:
patent: 5004735 (1991-04-01), Okamoto et al.
Chemical Abstracts, vol. 106, No. 7, Feb. 16, 1987, AN 46268d, P. Loew, et al., "Effectivity of Dolichyl Phosphates with Different Chain Lengths as Acceptors of Nucleotide Activated Sugars", p. 285.
Chemical Abstracts, vol. 103, No. 15, Oct. 14, 1985, AN 118321, P. Loew, et al., "Reaction of Optically Active S-and R-Forms of Dolichyl Phosphates with Activated Sugars", p. 277.
Cancer Letters, 57 (1991), pp. 159-163, Y. Okamoto, et al., "Inhibition of Growth and Pulmonary Metastasis of B16-F10 Murine Milanoma by N-1554, A Polyprenyl Phosphate".

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