(S)-1-[2- (4-(2-Hydroxy-s-(1-alkylaminopropoxy)phenylalkyl]-4-ph

Details (S)-1-[2- (4-(2-Hydroxy-s-(1-alkylaminopropoxy)phenylalkyl]-4-ph (S)-1-[2- (4-(2-Hydroxy-s-(1-alkylaminopropoxy)phenylalkyl]-4-ph

1978-02-08

1980-05-13

Rollins, Alton D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

260338, 2603409R, 26034845, 26034858, 260456A, 260556A, 260556AR, 544374, 544394, 560 55, 560254, 562430, 568644, 568649, 568650, 424250, A61K 31495, C07D29508, C07D29514

Patent

active

042029783

ABSTRACT:
There are disclosed compounds of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of lower alkyl; R.sub.8 is selected from the group consisting of --O--(CH.sub.2).sub.n --wherein n is 2 to 20, ##STR2## and R.sub.6 is selected from the group consisting of hydrogen or lower alkoxy, and ##STR3## wherein R.sub.1 is selected from the group consisting of lower alkyl; R.sub.8 is selected from the group consisting of --O--(CH.sub.2).sub.n --wherein n is 2 to 20, ##STR4## and R.sub.6 is selected from the group consisting of hydrogen or lower alkoxy and racemates thereof.
There are also disclosed processes and intermediates utilized to produce the end products.
The end products have utility as agents exhibiting both .alpha. and selective .beta. adrenergic blocking action.

REFERENCES:
British Heart Journal, vol. 35, pp. 588-596, 1974.

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