Ryegrass pollen allergen

Details Ryegrass pollen allergen Ryegrass pollen allergen

1995-05-02

1999-02-09

Elliott, George C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

4353201, 536236, C07H 2104, C12N 1500, C12N 1563

Patent

active

058693335

ABSTRACT:
The present invention provides nucleic acid sequences coding for two ryegrass pollen allergen Lol p Ib family members, purified Lol p Ib.1 and Lol p Ib.2 proteins and fragments thereof, methods of producing recombinant Lol p Ib.1 or Lol p Ib.2 or at least one fragment thereof or derivative or homologue thereof, and methods of using the nucleic acid sequences, proteins and peptides of the invention.

REFERENCES:
Bose, R. et al., "Production and Characterization of Mouse Monoclonal Antibodies to Allergenic Epitopes on Lolpl (Rye I)," Immunology, vol. 59, 309-315 (1986).
Brieva, A. and Rubio, N. "Rapid Purification of the Main Allergen of Lolium Prenne by High-Performance Liquid Chromatography," Journal of Chromatography, vol. 370, 165-172 (1986).
Chakrabarty, S. et al., "Detection of Cross-Reactive Allergens in Kentucky Bluegrass Pollen and Six Other Grasses by Crossed Radioimmunoelectrophoresis," Int. Archs. Allergy appl. Immun., vol. 66, 142-157 (1981).
Cook, R.M. et al., "Induction of Allergen-Specific T Cells by Conjugates of N-Formyl-Methionyl-Leucyl-Phenylalanine and Rye Grass Pollen Extract," Int. Archs Allergy appl. Immun., vol. 85, 104-108 (1988).
Cornford, C.A. et al., "IgE-Binding Proteins form Pine (Pinus radiata D. Don) Pollen: Evidence for Cross-Reactivity with Ryegrass (Lolium perenne)," Int. Arch Allergy Appl Immunol, vol. 93, 41-46 (1990).
Cottam, G. et al., "Immunological Properties of Chemically Produced Fragments of Rye Grass Pollen Extract," Immunology Letters, vol. 17, 345-350 (1988).
Cottam, G. et al., "Physiochemical and Immunochemical Characterization of Allergenic Proteins from Rye-Grass (Lolium perenne) Pollen Prepared by a Rapid and Efficient Purification Method," Biochem. J., vol. 234, 305-310 (1986).
Esch, R. and Klapper, D., "Isolation and Characterization of a Major Cross-Reactive Grass Group I Allergenic Determinant," Molecular Immunology, vol. 26, No. 6, 557-561 (1989).
Freidhoff, L. et al., "A Study of the Human Immune Response to Lolium perenne (Rye) Pollen and its Components, Lol p 1 and Lol p II (Rye I and Rye II)," J Allergy Clin Immunol, vol. 78, 1190-1201 (1986).
Freidhoff, L. et al., "A Study of the Human Immune Response to Lolium perenne (rye) Pollen and its Components, Lol p I and Lol p II (Rye I and Rye II)," J Allergy Clin Immunol, vol. 80, 646-655 (1987).
Freidhoff, L. et al., "Association of HLA-DR3 with Human Response to Lol p I and Lol p II Allergens in Allergic Subjects," Tissue Antigens, vol. 31, 211-219 (1988).
Griffith, I. et al., "Cloning and Sequencing of Lol pI, the Major Allergenic Protein of Rye-Grass Pollen," FEBS, vol. 279, No. 2, 210-215 (1991).
Hatton, T.W. et al., "Molecular Cloning of Kentucky (KBG) Pollen Alergens," J. Allergy Clin Immunol., vol. 81, No. 1, 183 (1988).
Hill, D.J. et al., "Specific Cellular and Humoral Immunity in Children with Grass Pollen Asthma," Clinical Allergy, vol. 12, 83-89 (1982).
Hopp, T. and Woods, K., "Prediction of Protein Antigenic Determinants from Amino Acid Sequences," Proc. Natl. Acad. Sci. USA, vol. 78, No. 6, 3824-3828 (1981).
Howlett, B.J. et al., "Cross-Reactivity Between Acacia (wattle) and Rye Grass Pollen Allergens," Clinical Allergy, vol. 12, 259-258 (1982).
Ishizaka, K. and Ishizaka, T., "Allergy," Fundamental Immunology, ch. 32, Second Edition, 867-888 (1989).
Kahn, C. and Marsh, D. "Monoclonal Antibodies to the Major Lolium Prenne (Rye Grass) Pollen Allergen Lol p I (Rye I)," Molecular Immunology, vol. 23, No. 12, 1281-1288 (1986).
Klein, J., Immunology The Science of Self-Nonself Discrimination, John Wiley & Sons, 550-551 (1982).
Kumar, V. et al., "Amino Acid Variations at a Single Residue in an Autoimmune Peptide Profoundly Affect Its Properties: T-cell Activation, Major Histocompatibility Complex Binding, and Ability to Block Experimental Allergic Encephalomyelitis," PNAS USA, vol. 87, No. 4, 1337-1341 (1990).
Lin, Z. et al., "Isolation and Characterization of Poa p I Allergens of Kentucky Bluegrass Pollen with a Murine Monoclonal Anti-Lol p I Antibody," Int Arch Allergy Immunol, vol. 87, 294-300 (1988).
Lin, Z. et al., "Mapping of Epitopes on Poa p I and Lol p I Allergens with Monoclonal Antibodies," Int Arch Allergy Appl Immunol, vol. 91, 217-223 (1990).
L.o slashed.wenstein, H., "Immunological Partial Identity and in vitro Inhibitory Effect of Two Major Timothy Pollen Allergens to Whole Pollen Extract of Four Grasses," Int. Archs Allergy appl. Immun., vol. 57, 379-383 (1978).
L.o slashed.wenstein, H., "Isolation and Partial Characterization of Three Allergens of Timothy Pollen," Allergy, vol. 33, 30-41 (1978).
L.o slashed.wenstein, H., "Timothy Pollen Allergens," Allergy, vol. 35, 188-191 (1980).
L.o slashed.wenstein, H. et al., "Purification of Timothy Pollen Allergens Followed by Quantitative Immunoelectrophoresis," Int. Archs Allergy appl. Immun., vol. 49, 95-98 (1975).
Margalit, H. et al., "Prediction of Immunodominant Helper T Cell Antigenic Sites from the Primary Sequence," The Journal of Immunology, vol. 138, No. 7, 2213-2229 (1987).
Marsh, D.G. et al., "Induction of IgE-Mediated Immediate Hypersensitivity to Group I Rye Grass Pollen Allergen and Allergoids in Non-Allergic Man," Immunology, vol. 22, 1013-1028 (1972).
Martin, R. et al., "Cross-Allergenicity Among the Grasses," Annals of Allergy, vol. 54, 99-104 (1985).
Matthiesen, F. and L.o slashed.wenstein, H., "Group V Allergens in Grass Pollens. I. Purification and Characterization of the Group V Allergen from Phleum pratense Pollen, Phl p V," Clinical and Experimental Allergy, vol. 21, 297-307 (1991).
Matthiesen, F. and L.o slashed.wenstein, H., "Group V Allergens in Grass Pollens. II. Investigation of Group V Allergens in Pollens from 10 Grasses," Clinical and Experimental Allergy, vol. 21, 309-320 (1991).
Matthiesen, F. et al., "Characteristics of Grass Pollen Allergens," Epitopes of Atopic Allergens, Proceedings of Workshop held under the Aegis of the XIV.sup.th Congress of the European Academy of Allergy and Clinical Immunology Berlin, 9-13 (Sep. 1989).
Mecheri, S. et al., "Purification and Characterization of a Major Allergen from Dactylis glomerata Pollen: The Ag Dg1," Int. Archs Allergy appl. Immun., vol. 78, 283-289 (1985).
Mohapatra, S. et al., "Isolation and Characterization of a cDNA Clone Encoding and IgE-Binding Protein from Kentucky Bluegrass (Pao pratensis) Pollen," Int Arch Allergy Appl Immunol, vol. 91, 362-368 (1990).
Mohapatra, S. et al., "Molecular Cloning of a Grass Pollen Allergens: Progress and Perspectives," Aerobiologia, vol. 6, 205-211 (1990).
Mourad, W. et al., "Allergenicity and Cross-Reactivity of Rye Grass Pollen Extracts Revealed by Monoclonal Antibodies," Journal of Immunological Methods, vol. 89, 53-59 (1986).
Mourad, W. et al., "Mapping of Lol p I Allergenic Epitopes by Using Murine Monoclonal Antibodies," Molecular Immunology, vol. 26, No. 11, 1051-1057 (1989).
Mourad, W. et al., "Study of the Epitope Structure of Purified DAC G I and Lol P I, the Major Allergens of Dactylis Glomerata and Lolium Perenne Pollens, Using Monoclonal Antibodies," The Journal of Immunology, vol. 141, No. 10, 3486-3491 (1988).
Olsen, E. et al., "Identification and Characterization of the PoaplX Group of Basic Allergens of Kentucky Bluegrass Pollen," The Journal of Immunology, vol. 147, 1-7 (1991).
Perez, M. et al., "cDNA Cloning and Immunology Characterization of the Rye Grass Allergen Lol p I," The Journal of Biological Chemistry, vol. 265, No. 27, 16210-16215 (1990).
Plotkin, S. and Mortimer, E., "New Technologies for Making Vaccines." Vaccines, ch 29, 568-575 (1988).
Silvanovich, A. et al., "Nucleotide Sequence Analysis of Three cDNAs Coding for Poa p IX Isoallergens of Kentucky Bluegrass Pollen," The Journal of Biological Chemistry, vol. 266, No. 2, 1204-1210 (1991).
Singh, M. and Knox, "Grass Pollen Allergens: Antigenic Relationships Detected Using Monoclonal Antibodies and Dot Blotting Immunoassay," Int. Archs. Allergy appl. Immun., vol. 78, 300-304 (1985).
Singh, M. et al., "Isolation of cDNA Endocing a Newly Identified Major Allergenic Protein of Rye-Grass Pollen: Intracellular Target

Affiliated with

Also associated with

Rating

Ryegrass pollen allergen does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ryegrass pollen allergen, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ryegrass pollen allergen will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1947926