Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1992-11-25
1996-09-03
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 71, 436501, G01N 3353, G01N 33566, C12Q 168
Patent
active
055522718
ABSTRACT:
The invention provides a method of screening a substance for the ability to effect the formation of a retinoid X receptor homodimer comprising combining the substance and a solution containing retinoid X receptors and determining the presence of homodimer formation. Also provided is a method of screening a substance for an effect on a retinoid X receptor homodimer's ability to bind DNA comprising combining the substance with the homodimer and determining the effect of the compound on the homodimer's ability to bind DNA. A method of inhibiting an activity of a retinoid X receptor heterodimer comprising increasing the formation of a retinoid X receptor homodimer, thereby preventing the retinoid X receptor from forming a heterodimer and preventing the resulting heterodimer activity is also provided. A method of inhibiting an activity of a retinoid X receptor homodimer is also provided. In addition, a method of screening a response element for binding with a retinoid X receptor homodimer is provided. Finally, the invention provides methods of activating retinoid X receptor homodimer formation.
REFERENCES:
Mangelsdorf et al, Nature 345:224 1990.
International Application No. PCT/US93/03944, Publication No. WO93/21146 28 Oct. 1993 Boehm et al., "Compounds Having Selectivity for Retinoid X Receptors" filed 22 Apr. 1993.
Bugge et al., The EMBO Journal 11:1409-1418 (1992).
Heyman et al., Cell 68:397-406 (1992).
Kliewer et al., Nature 355:446-449 (1992).
Leid et al., Cell 68:377-395 (1992).
Mangelsdorf et al., Cell 66:555-561 (1991).
Mangelsdorf et al., Genes & Development 6:329-344 (1992).
Marks et al., The EMBO Journal 11:1419-1435 (1992).
Oro et al., Nature 347:298-301 (1990).
Rottman et al., Molecular and Cellular Biology 11:3814-3820 (1991).
Tora et al., Cell 59:477-487 (1989).
Tzukerman et al., The New Biologist 2:613-620 (1990).
Yu et al., Cell 57:1251-1266 (1991).
Zhang et al., Nature 358:587-591 (1992).
Pfahl et al., Methods in Enzymology 189:256-270 (1990).
Cameron James F.
Dawson Marcia I.
Hobbs Peter D.
Jong Ling
Lehmann J urgen M.
La Jolla Cancer Research Foundation
Parsons Nancy J.
Scheiner Toni R.
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