RXR-agonist polycyclic aromatic compounds, pharmaceutical/cosmet

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514338, 514348, 514349, 514350, 514352, 514423, 514424, 514425, 514426, 514432, 514434, 514444, 514445, 514446, 514447, 514472, 514473, 514510, 514546, 514569, 514657, 514708, 514709, 514712, 514717, 514719, A61K 31395, A61K 3144

Patent

active

061628158

ABSTRACT:
Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds having the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## which are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders are provided. In particular, based on their RXR-agonist activity, these compounds may be used to treat noninsulin-dependent diabetes mellitus (NIDDM) and obesity.

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