RUNX3 gene showing anti-tumor activity and use thereof

Details RUNX3 gene showing anti-tumor activity and use thereof RUNX3 gene showing anti-tumor activity and use thereof

2001-01-30

2008-05-06

Yu, Misook (Department: 1642)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S006120

Reexamination Certificate

active

07368255

ABSTRACT:
The present invention relates to a RUNX3 gene showing anti-tumor activity which is essentially involved in TGF-β dependent-programmed cell death (apoptosis) and use thereof. In addition, the present invention finds that the RUNX3 gene expression is suppressed in the various gastric cancer and lung cancer cell lines. The suppression of the RUNX3 gene expression is due to hyper-methylation of CpG island located around RUNX3 exon (1). The RUNX3 gene and its gene product of the present invention can be used effectively for the development of anti-cancer agents. CpG island around RUNX3 exon (1) could also be used not only for the development of anti-cancer agents which regulate the abnormal DNA methylation and there by induce RUNX3 expression but also for the development of methods for cancer diagnosis by measuring the abnormal DNA methylation.

REFERENCES:
Levanon et al, Oncogene 23:4211-4219, 2004.
Kyeong-Sook Lee, et al., Runx2 Is a Common Target of Transforming Growth Factor β1 and Bone Morphogenetic Protein 2, and Cooperation between Runx2 and Smad5 Induces Osteoblast-Specific Gene Expression in the Pluripotent Mesenchymal Precursor Cell Line C2C12, Molecular and Cellular Biology, Dec. 2000, p. 8783-8792.
Scott C. Kogen, et al., ThePEBP2βMYH11Fusion Created Inv(16)(p13;q22) in Myeloid Leukemia Impairs Neutrophil Maturation and Contributes to Granulocytic Dysplasia, Proc. Natl. Acad. Sci. USA vol. 95, pp. 11863-11868, Sep. 1998.
S-C. Bae, et al., Regulation Mechanisms for the Heterodimeric Transcription Factor, PEBP2/CBF, Histol Histopathol (1999) 14: 1213-1221.
Suk Chul Bae, et al., Isolation ofPEBP2 alphaβcDNA Representing the Mouse Homolog of Human Acute Myeloid Leukemia Gene,AML1, Oncogene (1993), 8, 809-814.
Mee-Young, Ahn, et al., Comparison of the Human Genomic Structure of the Runt Domain-Encoding PEBP2/CBFalphaGene Family, Gene, 168 (1996) 279-280.
Amjad Javed, et al., Groucho/TLE/R-esp Proteins Associate with the Nuclear Matrix and Repress RUNX (CBFalpha/AML/PEBP2alpha)Dependent Activation of Tissue-Specific Gene Transcription, Journal of Cell Science113, 2221-2231 (2000).
Yen-Yee Tang, et al., Energetic and Functional Contribution of Residues in the Core Binding Factor β (CBF β) Subunit to Heterodimerization with CBFalpha, The Journal of Biological Chemistry, vol. 275, No. 50, p. 39579-39588, 2000.

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