RsbW-1 protein

Details RsbW-1 protein RsbW-1 protein

1999-05-12

2000-05-23

Brusca, John S.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530300, 435 691, C07K 500, C07K 1400, C12P 2100

Patent

active

060667176

ABSTRACT:
RsbW-1 polypeptides and DNA (RNA) encoding such RsbW-1 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such RsbW-1 for the treatment of infection, particularly bacterial infections. Antagonists against such RsbW-1 and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of RsbW-1 nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding SigB operon and for detecting the polypeptide in a host.

REFERENCES:
Wu et al., Sigma B, a putative operon encodong alternate sigma factor of Staphylococcus aureusRNA polymerase: molecular cloning and DNA sequencing, J. Bacteriology, vol. 178(20), pp. 6036-6042, Oct. 17, 1996.
Boylan, et al., "Activation of Bacillus subtilisTranscription Factor.sigma..sup.B by a Regulatory Pathway Responsive to Stationary-Phase Signals",; Journal of Bacteriology, vol. 174, No. 11, pp. 3695-3706 (Jun. 1992).
Kullick, et al., "The alternative sigma factor.sigma..sup.B in Staphylococcus aureus: regulation of the sigB operon in response to growth phase and heat shock"; Arch Microbiol 167, pp. 151-159; Springer-Verlag (1997).
Voelker, et al., "The Yeast Two-Hybrid System Detects Interactions between Bacillus subtilis .sigma..sup.B Regulators"; Journal of Bacteriology; vol. 178, No. 23, pp. 7020-7023 (Dec. 1996).
Voelker, et al., "Reactivation of the Bacillus subtilis Anti-.sigma..sup.B Antagonist, RsbV, by Stress--or Starvation-Induced Phosphatase Activities"; Journal of Bacteriology, vol. 178, No. 18, pp. 5456-5463, (Sep. 1996).
Alper, et al., "Role of Adenosine Nucleotides in the Regulation of a Stress-response Transcription Factor in Bacillus subtilis"; J.Mol. Biol. 260, pp. 165-177 (1996).
Yang, et al., "Opposing pairs of serine protein kinases and phosphatases transmit signals of enviromental stress to activate a bacterial transcription factor", Genes & Development10, pp. 2265-2275 (1996).
Voelker, et al., "Separate Mechanisms Activate .sigma..sup.B of Bacillus subtilis in Response to Environmental and Metabolic Stresses", Journal of Bacteriology, vol. 177, No. 13, pp. 3771-3780, (Jul. 1995).
Dufour, et al., :"Interactions between a Bacillus subtilis Anti-.sigma. Factor (RsbW) and Its Antagonist (RsbV)", Journal of Bacteriology, vol. 176, No. 7, pp. 1813-1820 (Apr. 1994).
Beloin, et al., GenBank Submission, Accession No. AB001488 "Characterization of an Irp-like (IrpC) gene from Bacillus subtilis".
Yang, et al., GenBank Submission, Accession No. AF034567 "Opposing pairs of serine protein kinases and phosphatases transmit signals of enviromental stress to activate a bacterial transcription factor".
Kullik, et al., GenBank Submission, Accession No. Y07645 "The alternative sigma factor sB in Staphylococcus aureus: regulation of the sigB operon in response to growth phase and heat shock".
Wu, et al., GenBank Submission, Accession No. Y09929 "Sigma-B, a putative operon encoding alternate sigma factor of Staphylococcus aureus RNA polymerase: molecular cloning and DNA sequencing".

Affiliated with

Also associated with

Rating

RsbW-1 protein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with RsbW-1 protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and RsbW-1 protein will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1837771