Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-09-26
2000-02-01
McKelvey, Terry
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435243, 4353201, 435325, 435410, 536 237, C12P 2102, C12N 100, C12N 510, C12N 1531
Patent
active
060201606
ABSTRACT:
RsbV-1 polypeptides and DNA (RNA) encoding such RsbV-1 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such RsbV-1 for the treatment of infection, particularly bacterial infections. Antagonists against such RsbV-1 and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of RsbV-1 nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding SigB operon and for detecting the polypeptide in a host.
REFERENCES:
Wu et al, J. of Bacteriology, Oct., 1996, vol. 178(20): pp. 6036-6042.
Takahashi et al, Molecular Biology of the Cell, Oct., 1994, vol. 5: pp. 1145-1158.
Ngo et al, The Protein Folding Problem and Tertiary Structure Prediction, Mertz et al (eds), pp. 445 and 492-495, Birkhauser, Boston (1994).
Voelker, et al., "The Yeast Two-Hybrid System Detects Interactions between Bacillus subtilis sigmaB Regulators." Journal of Bacteriology, vol. 178, No. 23, pp. 7020-7023, Dec. 1996.
Voelker, et al., "Reactivation of the Bacillus subtilis anti-oB Antagonist, RsbV, by Stress- or Starvation-Induced Phosphatase Activities." Journal of Bacteriology, vol. 178, No. 18, pp. 5456-5463, Sep., 1996.
Alper, et al., "Role of Adenosine Nucleotides in the Regulation of a Stress-response Transcription Factor in Bacillus subtilis ." JMB, vol. 260, No. 2, pp. 165-177, 1996.
Yang, et al., "Opposing pairs of serine protein kinases and phosphatases transmit signals of environmental stress to activate a bacterial transcription factor." Genes & Development, vol. 10, pp. 2265-2275, 1996.
Voelker, et. al., "Separate Mechanisms Activate o.sup.B of Bacillus subtilis in Response to Environmental and Metabolic Stresses." Journal of Bacteriology, vol. 177, No. 13, pp. 3771-3780, Jul., 1995.
Dufour, et al., "Interactions between a Bacillus subtilis Anti-o.sup.B Factor (RsbW) and its Antagonist (RsbV)." Journal of Bacteriology, vol. 176, No.7, pp.1813-1820, Apr., 1994.
Boylan, et. al., "Activation of Bacillus subtilis Transcription Factor o.sup.B by a Regulatory Pathway Responsive to Stationary-Phase Signals." Journal of Bacteriology, vol. 174, No. 11, pp. 3695-3706, Jun., 1992.
Kullik, et. al., "The Alternative sigma factor-o.sup.B in Staphylococcus aureus: regulation of the sigB operon in response to growth phase and heat shock." Arch Microbiology, vol. 167, pp. 151-159, 1997.
Kalman et al, J. of Bacteriology, vol. 172, pp. 5575-5585, 1990.
Fosberry Andrew P
Lawlor Elizabeth J
Nicholas Richard O
Deibert Thomas S.
Gimmi Edward R.
King William T.
McKelvey Terry
SmithKline Beecham Corporation
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