Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-12-06
2005-12-06
Nickol, G. (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S005000, C436S064000, C424S130100, C514S002600
Reexamination Certificate
active
06972179
ABSTRACT:
RRP genes are identified as modulators of the p53 or p21 pathway, and thus are therapeutic targets for disorders associated with defective p53 or p21 function. Methods for identifying modulators of p53 or p21, comprising screening for agents that modulate the activity of RRP are provided. Modulating agents identified using the methods of the invention can be used to specifically inhibit growth of tumor cells that overexpress an RRP protein. mRRP1 knockout mice are also provided.
REFERENCES:
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Belvin Marcia
Francis-Lang Helen
Friedman Lori
Larson Jeffrey S.
Plowman Gregory D.
Exelixis Inc.
Nickol G.
Yaen C.
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