(RR) and (RS stereoisomers of N-(7-ethoxycarbonylmethoxy-1,2,3,-

Details (RR) and (RS stereoisomers of N-(7-ethoxycarbonylmethoxy-1,2,3,- (RR) and (RS stereoisomers of N-(7-ethoxycarbonylmethoxy-1,2,3,-

1993-09-01

1994-09-13

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C22940, C07C22942

Patent

active

053470370

ABSTRACT:
A process for the preparation of a compound of formula (I) ##STR1## which is a (RR) and (RS) stereoisomer of N-(7-ethoxycarbonylmethoxy-1,2,3,4,-tetrahydronaphth-2-yl)-2-(3-chlorophen yl)-2-hydroxyethanamine and their pharmaceutically acceptable salts.

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patent: 4338333 (1982-07-01), Aimsworth
patent: 4382958 (1983-04-01), Duckworth
patent: 4707497 (1987-11-01), Cecchi et al.
patent: 4968679 (1990-11-01), Junge et al.
Bianchetti et al., British Journal of Pharmacology, (1990) vol. 100, pp. 831-839.
Drug Stereochemistry, Edited by Irving W. Wainer and Dennis E. Drayer (1988), pp. 245-247, and pp. 356-363.
Ariens; "Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology", European Journal of Clinical Pharmacology (1984), vol. 26, pp. 663-668.

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