RPDL protein and DNA encoding the same

Details RPDL protein and DNA encoding the same RPDL protein and DNA encoding the same

1996-09-23

1998-06-09

Degen, Nancy

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

4351721, 536 231, 536 2431, 536 2433, C12Q 168, C12N 1512, C07H 2104

Patent

active

057631824

ABSTRACT:
The 5'-terminal partial nucleotide sequence of each clone of a human fetal lung tissue CDNA library was determined. A clone having a novel sequence including a sequence homologous to that of the transcriptional control protein of a yeast was selected from among the above clones and its whole nucleotide structure was determined. It was confirmed that the protein encoded by the gene of the clone was a novel human transcriptional control protein (RPDL protein). Further, an expression vector for expressing the protein and a transformant obtained by transforming with such an expression vector can also be prepared.

REFERENCES:
Vidal and Gaber. RPD3 encondes a second facotr required to achieve maximum positive and negative transcriptional states in Saccharomyces cerevisiae. Mol. Cell. Biol. vol. 11(12):6317-6327, Dec. 1991.
Kijima et al., Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase. J. Biol. Chem. vol. 268(30):22429-22435, Oct. 25, 1993.
Strebhardt et al. Additional member of the protein-tyrosine kinase family: The src- and lck-related protooncogene c-tkl. PNAS (USA) vol. 84:8778-8782, Dec. 1987.
Marshall. Gene therapy's growing pains. Science. vol. 269:1050-1055, Aug. 25, 1995.

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