Rotomelt granulation

Details Rotomelt granulation Rotomelt granulation

1992-06-26

1995-07-04

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424499, 424501, 424502, A61K 916

Patent

active

054298253

ABSTRACT:
A process for producing granules by rotomelt granulation comprising mixing at least one powdered pharmaceutically active material and a powdered excipient material within a zone wherein both powdered materials are maintained in a fluidized state by a rising stream of gas in an apparatus having a rapidly rotating horizontal-disk located within a vertical vessel wherein said gas is at a temperature sufficient to cause at least one powdered material to at least partially melt thereby causing said powdered materials to aggregate and form granules.

REFERENCES:
patent: 4505953 (1985-05-01), Chen et al.
patent: 4871549 (1989-10-01), Ueda et al.
patent: 5019302 (1991-05-01), Sparks et al.
patent: 5028433 (1991-07-01), Ishimaru et al.
patent: 5104648 (1992-04-01), Denton et al.
patent: 5215755 (1993-06-01), Roche et al.
Handbook of Pharmaceutical Excipients, Am. Pharm. Assn., Washn. D.C., pp. 234 and 236, (1986).
The Merck Index, 11th Ed., Merck & Co., Rahway, N.J., pp. 7635, (1989).
The United States Pharmacopeia, USP XXII, NF XVII, U.S. Pharmacopeial Convention, Inc., Rockville, Md., p. 200 (1990).
Jager et al., "Effect of Material Motion on Agglomeration in the Rotary Fluidized-Bed Granulator", Drugs Made in Germany, vol. XXV, pp. 61-65, 1982.
Y. Haramushi et al., "Study on Fluidized Melt-Granulation I. Examination of the Factors on the Granulation", Yakugaku Zasshi, vol. 111, No. 9, pp. 515-523 (1991).

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