Rotogranulations and taste masking coatings for preparation of c

Details Rotogranulations and taste masking coatings for preparation of c Rotogranulations and taste masking coatings for preparation of c

1991-04-17

1993-06-01

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424441, 424469, 424470, 424474, 424494, 424495, 514974, A61K 936

Patent

active

052157555

ABSTRACT:
Chewable medicament tablets are made from coated rotogranules of a medicament wherein the rotogranules are formed from a granulation mixture of medicament, e.g. ibuprofen, polyvinylpyrrolidone, sodium starch glycolate and sodium lauryl sulfate and the rotogranules are coated with hydroxyethyl cellulose or a mixture of hydroxyethyl cellulose and hydroxypropyl methylcellulose and a process for making such tablets and a method of providing taste masking of medicaments utilizing such coated rotogranules in a tablet.

REFERENCES:
patent: 3594470 (1971-07-01), Borodkin
patent: 4800087 (1989-01-01), Mehta
patent: 4835187 (1989-05-01), Reuter
patent: 4835188 (1989-05-01), Ho
patent: 4837031 (1989-06-01), Denton
patent: 4851226 (1989-07-01), Julian
Naji M. Najib et al., "Characteristics of the invitro release of ibuprofen from polyvinylpyrrolidone solid dispersions", pp. 229-236.

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