Rotogranulations and taste masking coatings for preparation of c

Details Rotogranulations and taste masking coatings for preparation of c Rotogranulations and taste masking coatings for preparation of c

1993-03-19

1994-06-14

Phelan, Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424441, 424494, 424499, 424501, A61K 916, A61K 950

Patent

active

053208552

ABSTRACT:
Chewable medicament tablets are made from coated rotogranules of a medicament wherein the rotogranules are formed from a granulation mixture of medicament, e.g. ibuprofen, polyvinylpyrrolidone, sodium starch glycolate and sodium lauryl sulfate and the rotogranules are coated with hydroxyethyl cellulose or a mixture of hydroxyethyl cellulose and hydroxypropyl methylcellulose and a process for making such tablets and a method of providing taste masking of medicaments utilizing such coated rotogranules in a tablet.

REFERENCES:
patent: 3594470 (1971-07-01), Borodkin
patent: 4800087 (1989-01-01), Mehta
patent: 4835187 (1989-05-01), Reuter
patent: 4835188 (1989-05-01), Ho
patent: 4837031 (1989-06-01), Denton
patent: 4851226 (1989-07-01), Julian
patent: 4882169 (1989-11-01), Ventouras
N. M. Najib et al., "Characteristics of the invitro release of ibuprofen from polyvinylpyrrolidone solid dispersions", International Journal of Pharmaceutics, 32 (1986) pp. 229-236.

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