Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1995-06-01
1998-05-12
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
424 931, 424 932, 435 5, 4352351, A61K 3912, A61K 39295, C12N 700, C12Q 170
Patent
active
057501092
ABSTRACT:
The present invention provides novel rotavirus reassortants, vaccines employing the novel reassortants and methods for their preparation and administration. One such reassortant contains the gene encoding the v.p.7 neutralization antigen of a human rotavirus. Another reassortant contains the gene encoding the v.p.4 neutralization antigen of a human rotavirus. The remaining genes are provided solely from the bovine rotavirus WC3 strain, or from both the human and bovine strains.
REFERENCES:
patent: 3293129 (1966-12-01), Baker
patent: 4190645 (1980-02-01), Almeida
patent: 4205131 (1980-05-01), Almeida
patent: 4341763 (1982-07-01), Zygraich
patent: 4341870 (1982-07-01), Wyatt et al.
patent: 4571385 (1986-02-01), Greenberg et al.
patent: 4624850 (1986-11-01), Albert et al.
patent: 4636385 (1987-01-01), Plotkin et al.
patent: 4704275 (1987-11-01), Wyatt et al.
patent: 4751080 (1988-06-01), Wyatt et al.
patent: 4853333 (1989-08-01), Hsiao et al.
patent: 4861864 (1989-08-01), Atkinson et al.
patent: 4927628 (1990-05-01), Chanock et al.
patent: 5053406 (1991-10-01), Srnka et al.
patent: 5298244 (1994-03-01), Redmond et al.
patent: 5332658 (1994-07-01), Dyall-Smith et al.
patent: 5562685 (1996-10-01), Clark et al.
H F. Clark et al, "Rotavirus Isolate WI61 Representing a Presumptive New I!.
H F. Clark et al, "Rotavirus Vaccines", Vaccines, Plotkin S.A., Mortimer
H F. Clark et al, "Approaches to Immune Protection Against Rotavirus III!.
H F. Clark et al, "Serotype 1 Reassortant of Bovine Rotavirus WC3, Strain WI79-9, Induces a Polytypic Antibody Response in Infants", Vaccine,
H F. Clark et al, "Immune Protection of Infants Against Rotavirus Gastroenteritis by a Serotype 1 Reassortant of Bovine Rotavirus WC3", J.
H F. Clark et al, "Immune Response of Infants and Children to Low-Passage Bovine Rotavirus (Strain WC3)", Amer. J. Dis. Child., 140:350-356 (Apr.,
H F. Clark et al, "Diverse Serologic Response to Rotavirus Infection of Infants in a Single Epidemic", Ped. Infect. Dis., 4(6):626-631 (Nov.,
H F. Clark et al, "A Presumptive New Serotype of Human Rotavirus", 1986 ASM
H F. Clark et al, "Rotavirus Vaccine", Seminars Ped. Infect. Dis.,
H F. Clark et al, "Infant Responses to Bovine Rotavirus WC3 Reassortants Containing Human Rotavirus VP7, VP4 , or VP7+VP4", in Abstracts of the
P. Offit et al, "Molecular Basis of Rotavirus Virulence: Role of Gene
P. Offit et al, "Identification of the Two Rotavirus Genes Determining II!.
P. Offit et al, "Reassortant Rotaviruses Containing Structural Proteins vp3 and vp7 from Different Parents Induce Antibodies Protective Against each
P. Offit et al, "Maternal Antibody-Mediated Protection Against Gastroenteritis due to Rotavirus in Newborn Mice is Dependent on both Serotype and Titer of Antibody", J. Infect. Dis., 152(6):1152-1158 (Dec.,
P. Offit et al, "Outer Capsid Glycoprotein vp7 is Recognized by Cross-Reactive, Rotavirus-Specific, Cytotoxic T Lymphocytes", Virology,
P. Offit et al, "Rotavirus-Specific Cytotoxic T Lymphocyte Response of Mice after Oral Inoculation with Candidate Rotavirus Vaccine Strains RRV or
K. Midthun et al, "Single Gene Substitution Rotavirus Reassortants Containing the Major Neutralization Protein (VP7) of Human Rotavirus
K. Midthun et al, "Reassortant Rotaviruses as Potential Live Rotavirus
Y. Hoshino et al, "Independent Segregation of Two Antigenic Specificities (WP3 and VP7) Involved in Neutralization of Rotavirus Infectivity", Proc.
Y. Hoshino, "Genetic Studies of Rotavirus Virulence", Summary, Third NIH
R. Daum et al, "New Developments in Vaccines", Advances in Pediatric Infectious Diseases, vol. 6, pp. 1-57 (1991).
J. Walsh et al, "Special Article -- Selective Primary Health Care--An Interim Strategy for Disease Control in Developing Countries", New Eng. J. Med., 301(18):967-974 (Nov., 1979).
I. deZoysa et al, "Interventions for the Control of Diarrhoeal Diseases Among Young Children: Rotavirus and Cholera Immunization", Bull WHO, 63(3):569-583 (1985).
M-S. Ho et al, "Morbidity and Mortality Associated with Rotavirus Diarrhea in the U.S.", 27th Interscience Conf. Antimicrobiol Agents Chemotherapy, Abstract No. 13 (1987).
M. Estes et al, "Antigenic Structure of Rotaviruses", Immunochemistry of
M. Estes et al, "Molecular Biology and Immunology of Rotavirus Infections",
M. Estes, "Rotaviruses and Their Replication", Ch. 48 in Virology, 2d ed.,
R. Wyatt et al, "Definition of Human Rotavirus Serotypes by Plaque Reduction Assay", Infect. and Immun., 37 (1):110-115 (Jul., 1982).
S. Matsuno et al, "A Candidate for a New Serotype of Human Rotavirus", J.
S. Matsuno et al, "Plaque Assay of Neonatal Calf Diarrhea Virus and the Neutralizing Antibody in Human Sera", J. Clin. Microbiol., 5(1):1-4 (Jan.,
"WHO News and Activities", Bull WHO, 67(5):583-587 (1989).
A. Kalica et al, "Identification of the Rotavirus Gene that Codes for Hemagglutination and Protease-Enhanced Plaque Formation", Virol.,
A. Kalica et al, "Genes of Human (Strain Wa) and Bovine (Strain UK) Rotaviruses that Code for Neutralizatin and Subgroup Antigens", Virol.,
H. Greenberg et al, "Rescue and Serotypic Characterization of Noncultivable Human Rotavirus by Gene Reassortment", Infec. and Immunol., 37(1):104-109
H. Greenberg et al, "Rescue of Noncultivatable Human Rotavirus by Gene Reassortment During Mixed Infection with ts mutants of a Cultivatable Bovine Rotavirus", Proc. Natl. Acad. Sci. USA, 78(1):420-424 (Jan., 1981)
R. Ward et al, "Serum-Neutralizing Antibody to VP4 and VP7 Proteins in Infants Following Vaccination with WC3 Bovine Rotavirus", J. Virol.,
R. Ward et al, "Phenotypic Mixing During Coinfection of Cells with Two Strains of Human Rotavirus", J. Virol., 62(11):4358-4361 (1988),
E. Wenske et al, "Genetic Reassortment of Mammalian Reoviruses in Mice", J. Virol., 56(2):613-616 (Nov., 1985).
I. Perez-Schael et al, "Clinical Studies of a Quadrivalent Rotavirus Vaccine in Venezuelan Infants", J. Clin. Microbiol., 28(3):553-558 (Mar., 1990).
O. Nakagomi et al, "Molecular Identification of a Novel Human Rotavirus in Relation to Subgroup and Electropherotype of Genomic RNA", J. Med. Virol.,
O. Nakagomi et al, "Identification of Rotavirus Genogroups by RNA-RNA
O. Nakagomi et al, "Genetic Analysis of a Human Rotavirus that Belongs to Subgroup I but has an RNA Typical of Subgroup II Human Rotaviruses", J.
T. Nakagomi et al, "Relative Frequency of Human Rotavirus Subgroups I and II in Relation to Short and Long Electropherotypes of Viral RNA", Ann. Inst. Pasteur/Virol., 139:295-300 (Jul.-Sep., 1988).
A. Graham et al, "Reassortment of Human Rotavirus Possessing Genome Rearrangements with Bovine Rotavirus: Evidence for Host Cell Selection", J. Gen. Virol., 68:115-122 (Jan., 1987).
G. Losonsky et al, "Safety, Infectivity, Transmissibility and Immunogenicity of Rhesus Rotavirus Vaccine (MMU 18006) in Infants", Pediatr. Inf. Dis., 5(1):25-29 (Jan., 1986).
T. Vesikari et al, "A Comparative Trial of Rhesus Monkey (RRV-1) and Bovine (RIT 4237) Oral Rotavirus Vaccines in Young Children", J. Infect. Dis.,
T. Vesikari et al, "Immunogenicity and Safety of Live Oral Attenuated Bovine Rotavirus Vaccine Strain RIT 4237 in Adults and Young Children",
T. Vesikari et al, "Protective Efficacy Against Serotype 1 Rotavirus Diarrhea by Live Oral Rhesus-Human Reassortant Rotavirus Vaccines with Human Rotavirus VP7 Serotype 1 or 2 Specificity", Pediatr. Infect. Dis.
D. Chen et al, "Phenotypes of Rotavirus Reassortants Depend Upon the Recipient Genetic Background", Proc. Natl. Acad. Sci. USA, 86:3743-3747 (May, 1989).
S. Urasawa et al, "Genetic Reassortment Between Two Human Rotaviruses Having Different Serotype and Subgroup Specificities", J. Gen. Virol., 67:1551-1559 (1986).
T. Urasawa et al, "Preparation of a Human Rotavirus Reassortant with Dual Serotype Specificity of VP3 of Serotype 4 and vp7 of Serotype 3", Sapporo Igaku Zasshi, 57(4):373-378, Biological Abstracts, Abstract No. 87033161 (1988).
A. Kapikian et al, "Development of a Rotavirus (RV) Vaccine by a Jennerian and a Modified Jennerian Approach", Modern Approaches to New Vaccines,
A. Kapikain et al, "Antigenic Characterization o
Clark H. Fred
Offit Paul
Plotkin Stanley A.
Robinson Douglas W.
The Children's Hospital of Philadelphia
The Wistar Institute of Anatomy & Biology
Wai Thanda
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