Rotavirus inner capsid subunit preparations

Details Rotavirus inner capsid subunit preparations Rotavirus inner capsid subunit preparations

1978-08-30

1980-02-26

Rosen, Sam

Drug, bio-affecting and body treating compositions

Lymphokine

435317, 435236, A61K 3912, C12K 700

Patent

active

041906454

ABSTRACT:
A preparation of rotavirus inner capsid antigenic subunits which is substantially free from complete virus particles and fragments thereof. The subunits have a sedimentation coefficient of 17.5S, and a molecular weight of >2.times.10.sup.5 and >2.times.10.sup.6. Such a preparation can be prepared by suspending a sample of faecal material obtained from a mammal infected with rotavirus, incubating the suspension followed by the removal and concentration of the subunits from the suspension by centrifugation and/or filtration. Such a preparation is useful in several immunological tests and for the preparation of antisera also for use in tests.

REFERENCES:
Rodgers et al., Chem. Abst. vol. 87 (1977) p. 180,409t.
Newman Nature, vol. 258 (Dec. 18, 1975) pp. 631-633.

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