Rotavirus antigens

Details Rotavirus antigens Rotavirus antigens

1988-06-13

1989-08-29

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530350, 424 88, 424 89, C07K 710, C07K 1300

Patent

active

048618640

ABSTRACT:
A soluble form of the neutralizing antigen or rotavirus is provided. The antigen is formed by cloning DNA coding for VP7 protein into an expression vector and preparing deletion mutants coding for a soluble cell secreted neutralizing antigen. The preparation of the deletion mutants includes the removal of the DNA sequences coding for those amino acids of the VP7 protein responsible for its normal intracellular location and non-secretion characteristics. The deletion mutant may be used in the formation of stably transformed animal cell lines which contiuously secrete the antigen, or in the production of certain yeast strains which produce the soluble antigen with appropriate glycosylation.

REFERENCES:
Chem. Abstr., vol. 104, (1986), 223138.
Chem. Abstr., vol. 103, (1985), 34597.
Chem. Abstr., vol. 102, (1985), 92595.
Chem. Abstr., vol. 99, (1983), 209362.
Chem. Abstr., vo. 100, (1984), 117536.
Chem. Abstr., vol. 106, (1987), 194265.
Chem. Abstr., vol. 106, (1987), 169950.
Chem. Abstr., vol. 105, (1986), 222513.
Chem. Abstr., vol. 104, (1986), 46516.
Chem. Abstr., vol. 104, (1986), 146775.
Chem. Abstr., vol. 104, (1986), 86653.
J. of Virulogy, (1985), 791-797, vol. 54.
Chem. Abstr., vol. 104, (1986), 46459a.

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