Room temperature-curable polymers

Details Room temperature-curable polymers Room temperature-curable polymers

2011-03-15

2011-03-15

Hartley, Michael G (Department: 1618)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

Reexamination Certificate

active

07906134

ABSTRACT:
Methods of making room temperature-curable polymers. Reactants include siloxane-terminated polymers and silanols. The reactants are mixed, and the polymerization allowed to proceed in air at room temperature. The polymers are exceptionally useful because they allow for the incorporation into the polymers themselves of one or more therapeutic compounds. Thus, medical devices from which controlled drug release is desirable (for either local or systemic delivery) can be coated with therapeutic compound-containing polymers of the invention. In a preferred embodiment, a polymer of poly(MPCw:LAMx:HPMAy:TSMAz) where w, x, y, and z represent the molar ratios of monomers used in the feed for preparing the polymer; MPC represents the unit 2-methacryoyloxyethylphosphorylcholine, LMA represents the unit lauryl methacrylate, HPMA represents the unit 2-hydroxypropyl methacrylate, and TSMA represents the unit 3-trimethoxysilylpropyl methacrylate is reacted with polydimethylsiloxane. In another preferred embodiment, a therapeutic compound is incorporated into the polymer, such as dexamethasone.

REFERENCES:
patent: 4742092 (1988-05-01), Inoue et al.
patent: 5648442 (1997-07-01), Bowers et al.
patent: 5705583 (1998-01-01), Bowers et al.
patent: 5969075 (1999-10-01), Inoue
patent: 6015815 (2000-01-01), Mollison
patent: 6090901 (2000-07-01), Bowers et al.
patent: 6284854 (2001-09-01), Bowers et al.
patent: 2005/0208093 (2005-09-01), Glauser et al.
patent: 0604851 (1994-07-01), None
patent: WO 03/022324 (2003-03-01), None
Lewis, A.L., Z.L. Cumming, H.H. Goreish, L.C. Kirkwood, L.A. Tolhurst, and P.W. Stratford. 2001. Crosslinkable coatings from phosphorylcholine-based polymers. Biomaterials. 22:99-111.
Lewis, A.L., P.D. Hughes, L.C. Kirkwood, S.W. Leppard, R.P. Redman, L.A. Tolhurst, and P.W. Stratford. 2000. Synthesis and characterisation of phosphorylcholine-based polymers useful for coating blood filtration devices. Biomaterials. 21:1847-59.
International Search Report for PCT/US06/62066, filed Dec. 14, 2006, mailed Oct. 17, 2007, 7 pgs.

Affiliated with

Also associated with

Rating

Room temperature-curable polymers does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Room temperature-curable polymers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Room temperature-curable polymers will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2719902