Roller bottle system

Details Roller bottle system Roller bottle system

1987-11-24

1989-05-09

Scott, Samuel

Chemistry: molecular biology and microbiology

Apparatus

Bioreactor

435285, 366233, C12M 124

Patent

active

048290041

ABSTRACT:
An insert for a roller bottle of the type used in cell culture for vaccine manufacture is formed of a polymeric resilient material whereby it can be bent or rolled so that it can pass through the opening of the roller bottle. Once the insert is inside the bottle, it is released so that its resilient characteristic causes it to unbend or unroll. The insert is wider than the diameter of the roller bottle, and therefore it is urged against the interior wall of the roller bottle. Apertures and/or notches are provided in the insert to increase the turbulence of a fluid and to decrease the fluidic shear forces in the roller bottle as it is rotated in conventional operation. A significant increase in productivity is achieved because particles, which may be microcarrier beads, are maintained in suspension, and prevented from sinking to the bottom of the fluid medium where cells cannot grow. The roller bottle system is thereby transformed into a microcarrier suspension culture system.

REFERENCES:
patent: 707986 (1902-08-01), Tolhurst et al.
patent: 3941661 (1976-03-01), Noteboom
patent: 4062995 (1977-12-01), Korpman
patent: 4167599 (1979-09-01), Nissinen
patent: 4317886 (1982-03-01), Johnson et al.
patent: 4535020 (1985-08-01), Thomas et al.
patent: 4600622 (1986-07-01), Carlson et al.
patent: 4734373 (1988-03-01), Bartal

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