Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of culturing cells in suspension
Patent
1996-09-16
1999-02-02
Beisner, William H.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of culturing cells in suspension
4352881, 4352982, 4352992, 4353041, 215382, 215DIG8, C12N 500, C12M 124
Patent
active
058664190
ABSTRACT:
The invention is a roller bottle having a cross-section that is substantially a non-circular closed curve of constant width, wherein said curve is preferably a Reuleaux triangle or a Reuleaux triangle with rounded corners and the use of the roller bottle for cell culture. This provides several benefits: 1) a larger surface area per unit volume than a circular cross-section, promoting growth of anchorage dependant cells while maintaining an easily harvested and cleaned smooth wall. 2) a translational motion in addition to the usual circular motion, which is expected to enhance gas exchange, especially at the cap, which normally sits on an axis and has low angular velocity. 3) greater agitation of the growth medium inside the bottle, without the need for difficult to manufacture inserts or internal baffles.
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