Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – The nonhuman animal is a model for human disease
Reexamination Certificate
2005-04-12
2005-04-12
Crouch, Deborah (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
The nonhuman animal is a model for human disease
C800S008000, C424S009200, C514S04400A
Reexamination Certificate
active
06878858
ABSTRACT:
The present invention provides an animal model for Parkinson's Disease and a method for generating such a model. The method comprises the steps of transfecting dopaminergic neurons in the substantia nigra with a dominant negative mutant of FGFR1 with deleted tyrosine kinase domain. The animals are characterized by a reduction in the number of tyrosine hydroxylase neurons in the SNc area.
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Peng, et al., Novel Nuclear Signaling Pathway Mediates Activation of Fibroblast Growth Factor-2 Gene by Type 1 and Type 2 Angiotensin II Receptors, Molecular Biology of the Cell, vol. 12, Feb. 2000, pp. 449-462.
Belluardo, et al.Comparative Localization of Fibroblast Growth Factor Receptor -1, -2, and -3 mRNAs in the Rat Brain: In Situ Hybridization Analysis, The Journal of Comparative Neurology, 1997, vol. 379, No. 2, pp. 226-246.
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Crouch Deborah
Hodgson & Russ LLP
The Research Foundation of State University of New York
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