Surgery – Diagnostic testing
Patent
1995-11-03
1998-09-01
Jaworski, Francis
Surgery
Diagnostic testing
128923, A61B 500
Patent
active
058003479
ABSTRACT:
A method of assessing risk of an individual for a disease is disclosed. A level of a marker for the disease is detected, and the risk of disease is computed from a statistical analysis of the marker level distributions for tested normal and diseased populations, using multivariate distributions. The computed risk is compared to thresholds to triage the individual into a normal, borderline, or elevated risk group, and a course of action based on the risk group is determined. Memory storing a program for execution on a data processing system, as well as a computer system comprising said memory is also disclosed, the memory comprising a receiver for signals representative of levels of a marker for the disease; a central procesing unit for computing risk of disease from one or more levels of the marker, and for comparing the computed risk to thresholds to triage the individual; and storage medium for the marker levels for subsequent computations of risk of disease.
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Cronin, K.A. et al., "Using the Gibbs Sampler to Detect Changepoints: Application to PSA as a Longitudinal Marker for Prostate Cancer", Computing Sci. and Statistics, 26th Symp. on the interface, Research Triangle Park, NC (Jun. 1994).
Jacobs, I. and Oram, D. (Study Directors), "Randomised Trial of Screening for Ovarian Cancer", Ovarian Cancer Screening Unit, The Royal Hospitals Trust, St. Bartholomew's Hospital, London EC1A 7BE.
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Jacobs Ian
Skates Steven J.
Jaworski Francis
The General Hospital Corporation
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