Surgery – Diagnostic testing – Measuring or detecting nonradioactive constituent of body...
Patent
1997-02-03
1998-11-03
Nasser, Robert L.
Surgery
Diagnostic testing
Measuring or detecting nonradioactive constituent of body...
600316, 600322, A61B 500
Patent
active
058301321
ABSTRACT:
An improved method and apparatus for determining noninvasively and in vivo one or more unknown values of a known characteristic, particularly the concentration of an analyte in human tissue. The method includes: (1) irradiating the tissue with infrared energy (400 nm-2400 nm) having at least several wavelengths in a given range of wavelengths so that there is differential absorption of at least some of the wavelengths by the tissue as a function of the wavelengths and the known characteristic, the differential absorption causeing intensity variations of the wavelengths incident from the tissue; (2) providing a first path through the tissue; (3) optimizing the first path for a first sub-region of the range of wavelengths to maximize the differential absorption by at least some of the wavelengths in the first sub-region; (4) providing a second path through the tissue; and (5) optimizing the second path for a second sub-region of the range, to maximize the differential absorption by at least some of the wavelengths in the second sub-region. In the preferred embodiment a third path through the tissue is provided for, which path is optimized for a third sub-region of the range. With this arrangement, spectral variations which are the result of tissue differences (e.g., melanin and temperature) can be reduced. At least one of the paths represents a partial transmission path through the tissue. This partial transmission path may pass through the nail of a finger once and, preferably, twice. Also included are apparatus for: (1) reducing the arterial pulsations within the tissue; and (2) maximizing the blood content i the tissue.
REFERENCES:
patent: 4570638 (1986-02-01), Stoddart et al.
patent: 4768516 (1988-09-01), Stoddart et al.
patent: 4880304 (1989-11-01), Jaeb et al.
patent: 4883963 (1989-11-01), Kemeny et al.
patent: 5028787 (1991-07-01), Rosenthal et al.
patent: 5077476 (1991-12-01), Rosenthal
patent: 5120961 (1992-06-01), Levin et al.
patent: 5139025 (1992-08-01), Lewis et al.
patent: 5188108 (1993-02-01), Secker
patent: 5222496 (1993-06-01), Clarke et al.
"Post-Prandial Blood Glucose Determination by Quantitative Mid-Infrared Spectroscopy", K.J. Ward, et al., Applied Spectroscopy, vol. 46, No. 6, 1992, pp. 959-965.
"Reagentless Near-Infrared Determination of Glucose in WHole Blood Using Multivariate Calibration", David M. Haaland, et la., Applied Spectroscopy, vol. 46, No. 10, 1992, pp. 1575-1578.
"Noninvasive Glucose Monitoring in Diabetic Patients: A Preliminary Evluation", M. Ries Robinson, et al., Clinical Chemistry, vol. 38, No. 9, 1992, pp. 1618-1621.
"Near-IR Fiber-Optic Probe for Electrolytes in Aqueous Solution", Jie Lin, et al., Analytical Chemistry, vol. 65, No. 3, Feb. 1, 1993, pp. 287-292.
"The Optics of Human Skin", R. Rox Anderson, et al., The Journal of Investigative Dermatology, vol. 77, No. 1, Jul. 1981, pp. 13-19.
"Acousto-Optic Devices, Optical Elements for Spectroscopy", Chieu D. Tran, Analytical Chemistry, vol. 64, No. 20, Oct. 15, 1992, pp. 971A-981A.
"Defense-Related Acousto-Optics Transform Commercial Products", Ronald G. Rosemeier, Photonics Spectra, Jan. 1993, pp. 83-84.
Morgan DeWitt M.
Nasser Robert L.
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