Ro/SSA peptide reagents for diagnosis of autoantibodies

Details Ro/SSA peptide reagents for diagnosis of autoantibodies Ro/SSA peptide reagents for diagnosis of autoantibodies

2005-05-24

2005-05-24

Nolan, Patrick J. (Department: 1644)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

11 to 14 amino acid residues in defined sequence

C530S326000, C530S328000, C435S071100

Reexamination Certificate

active

06897287

ABSTRACT:
A number of octapeptides were generated from the sequences encoding the 60 kDa Ro/SSA peptide, the La/SSB autoantigen, the 70 kD nuclear ribonucleoprotein (nRNP), and the Sm B/B′ polypeptide, which represent linear epitopes for autoantibodies present in the sera of SLE and SS patients. These peptides are useful in solid phase assays for patients characterized by the presence of these autoantibodies, and can be used to categorize patients as to the likelihood of developing certain conditions associated with SLE. The peptides are also potentially useful in treatment of these patients using immobilized peptide to remove autoantibody and to block binding of the autoantibodies with patient molecules reactive with the autoantibodies.

REFERENCES:
patent: 4554101 (1985-11-01), Hopp
patent: 4784942 (1988-11-01), Harley
patent: 4865970 (1989-09-01), Brot et al.
patent: 5312752 (1994-05-01), Wotiz et al.
patent: A0313156 (1989-04-01), None
patent: WOA8809932 (1988-06-01), None
patent: WOA9111718 (1991-08-01), None
patent: 9117171 (1991-11-01), None
Barakat et al. Clin. exp. Immunol. 89: 38-45 1992.*
Voller et al. Manual of Clinical Laboratory Immunology 1986 See Chpt 17.*
Dyrberg et al. Current Topics in Microbiol. 130:25-37 1986.*
Geysen et al. J. Imm. Methods 102:259-274 1987.*
Ferris and Donaldson,Veterinary Microbiologyvol. 18 No. 3-4, pp. 243-258 (1988).
Mosier, et al.,Naturevol. 335, pp. 256-259 (1988).
Dickey, W.D.,Human Autoantibody Producing Grafts in SCID Mice,presented to the Oklahoma Lupus Association, Sep. (1989) (Abstract).
Tigbe,Production of human rheumatoid factors (RF) by SCID mice transplanted with synovial membrane lymphocytes,presented at the Arthritis Foundation Fellows Conference, Amelia Island, Plantation, Florida, Dec. 8-10, 1989.
Guldner, et al.,The Journal of Immunology,vol. 141, No. 2, pp. 469-475 (Jul. 15, 1988).
Schaack, pp. 581-588, inAnnals of Internal Medicinevol. 111, No. 7, pp. 581-591 (Oct. 1, 1989).
Scofield and Harley,Proceedings of the National Academy of Sciences U.S.A.vol. 88, pp. 3343-3347 (Apr. 15, 1991).
Ben-Chetrit, Eldad, et al., “Isolation and Characterization of a cDNA Encoding the 60-kD Component of the Human SS-A/Ro Ribonucleoprotein Autoantigen,”J. Clin. Inv83:1284-1292.
Chambers, Jasemine C., et al., “Genomic Structure and Amino Acid Sequence Domains of the Human La Autoantigen,”J. Biol. Chem.263:18043-18051 (1988).
Chambers, Jasemine Choy and Jack D. Keene, “Isolation and analysis of cDNA clones expressing human lupus La antigen,”Proc. Natl. Acad. Sci. USA82:2115-2119 (1985).
Chan, E.K.L., et al., “Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding,”Nucl. Acids Res.17:2233-2244 (1989).
Deutscher, Susan L., et al., “Molecular analysis of the 60-kDa human Ro ribonucleoprotein,”Proc. Natl. Acad. Sci. USA85:9479-9483 (1988).
Elkon, Keith B., et al., “Epitope Mapping of Recombinant HeLa SmB and B' Peptides Obtained by the Polymerase Chain Reaction,”J. of Immun.145:636-643 (1990).
McAlister, George, et al., “cDNA sequence of the rat U snRNP-associated protein N: description of a potential Sm epitope,”EMBO Jour.8:1177-1181 (1989).
Renz, M., et al., “Expression of the Major Human Ribonucleoprotein (RNP) Autoantigens inEscherichia coliand Their Use in an EIA for Screening from Patents with Autoimmune Diseases,”Clin. Chem.35:1861-1863 (1989).
Rokeach, Luis A., et al., “Primary Structure of a Human Small Nuclear Ribonucleoprotein Polypeptide as Deduced by cDNA Analysis,”J. of Biol. Chem.264: 5024-5030 (1989).
Sharpe, N.G., et al., “Isolation of cDNA clones encoding the human Sm B/B' auto-immune antigen and specifically reacting with human anti-Sm auto-immune sera,”FEBS Letter250:585-590 (1989).
Sillekens, Peter T. G., et al., “cDNA cloning of the human U1 snRNA-associated A protein: extensive homology between U1 and U2 snRNP-specific proteins,”EMBO Journal6:3841-3848 (1987).
Sturgess, Allan D., et al., “Characteristics and Epitope Mapping of a Cloned Human Autoantigen La.”J. Immun.3212-3218 (1988).
Yamamoto, Kazuhiko, et al., “Isolation and Characterization of a Complementary DNA Expressing Human U1 Small Nuclear Ribonucleoprotein C Polypeptide,”J.Immun.140:311-317 (1988).
J. Gen. Microbiology 135(7): 1895-1899 1989.*
James, Judith A. and John B. Harley, “Linear Epitope Mapping of an Sm B/B1Polypeptide,”J. of Immun.146:2074-2079 (1992).

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