Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-09-20
2005-09-20
Celsa, Bennett (Department: 1639)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S440000
Reexamination Certificate
active
06946247
ABSTRACT:
The present invention relates to the field of immunology, and more particularly to the regulation of antibody idiotypes. Provided are compositions and methods for determining and quantitating immunoglobulin germline transcript expression. As disclosed herein, these methods can be used to screen a plurality of candidate agents to identify a candidate agent capable of modulating an immunoglobulin germline transcript. Further, these methods can be used to identify a candidate agent having different modulatory effects on distinct immunoglobulin germline transcripts.
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Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the 1.29 mu B cell line, Qiu G, Stavnezer J., J. Immunol., Sep. 15, 1998;161(6):2906-18.
Berton MT, Vitetta Es. IL-4-induced expression of germline gamma 1 transcripts in B cells following cognate interactions with T helper cells. Int Immunol. Mar. 1992;4(3):387-96.
Berton MT, et al. Synthesis of germ-line gamma 1 immunoglobulin heavy-chain transcripts in resting B cells: induction by interleukin 4 and inhibition by interferon gamma. Proc Natl Acad Sci U.S.A. Apr. 1989;86(8):2829-33.
Jardieu P. Anti-IgE therapy. Curr Opin Immunol. Dec. 1995;7(6):779-82.
Shields RL, et al. Inhibition of allergic reactions with antibodies to IgE. Int Arch Allergy Immunol. May-Jun 1995;107(1-3):308-12.
Turaga PS, Berton MT, Teale JM. Frequency of B cells expressing germ-line gamma 1 transcripts upon IL-4 induction J. Immunol. Aug. 1, 1993;151(3):1383-90.
Warren WD, Berton MT. Induction of germ-line gamma 1 and epsilon Ig gene expression in murine B cells. IL-4 and the CD40 ligand-CD40 interaction provide distinct but synergistic signals. J Immunol. Dec. 15, 1995;155(12):5637-46.
Bogenberger Jakob M.
Swift Susan E.
Celsa Bennett
Lahive & Cockfield LLP
Rigel Pharmaceuticals Inc.
Smith DeAnn F.
Williams Megan E.
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