Chemistry: molecular biology and microbiology – Vector – per se
Patent
1997-09-04
2000-05-09
Wortman, Donna
Chemistry: molecular biology and microbiology
Vector, per se
435 693, 4241861, 4241991, 4242041, 4242111, 4242181, 424 936, 514 44, C12N 1545
Patent
active
060603089
ABSTRACT:
A vector comprising a first DNA sequence which is complementary to at least part of an alphavirus RNA genome and having the complement of complete alphavirus DNA genome replication regions, a second DNA sequence encoding a paramyxovirus protein, particularly a respiratory syncytial virus fusion (RSV F) protein or a RSV F protein fragment that generates antibodies that specifically react with RSV F protein, the first and second DNA sequences being under the transcriptional control of a promoter is described. Such vector may be used to produce an RNA transcript which may be used to immunize a host, including a human host, to protect the host against disease caused by paramyxovirus, particularly respiratory syncytial virus, by administration to the host.
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Connaught Laboratories Limited
Wortman Donna
Zeman Mary K
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