Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2007-01-02
2007-01-02
Qian, Celine (Department: 1636)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C536S023100
Reexamination Certificate
active
09952013
ABSTRACT:
The present invention relates to an RNA polymerase I transcription factor TIF-IA and proteins related thereto, whose concentration and/or activity are correlated with the cell proliferation rate, and to DNA sequences encoding these proteins. The present invention also concerns ligands binding to an RNA polymerase I transcription factor TIF-IA and proteins related thereto, respectively, antagonists as well as antisense RNAs and/or ribozymes, directed against the TIF-IA expression. These compounds are of use for the prevention or treatment of diseases associated with an increased or reduced cell proliferation.
REFERENCES:
patent: WO 99/06549 (1999-02-01), None
Sequence alignment of SEQ ID No:242 from WO 99/06549 with SEQ ID No: 1 of the instant application.
Andreas Schnapp et al., “Function of the Growth-Regulated Transcription Initiation Factor TIF-IA in Iniation Complex Formation at the Murine Ribosomal Gene Promoter”, Molecular and Cellular Biology, Nov. 1993, pp. 6723-6732, vol. 13, No. 11, American Society for Microbiology.
National Cancer Institute, cancer genome anatomy project (CGAP), “Genbank” accession No. AA213789, Feb. 1997.
Beth Moorefield et al., “RNA Polymerase I Transcription Factor Rrn3 is Functionally Conserved Between Yeast and Human”, Proc. Natl. Acad. Sci., Apr. 25, 2000, pp. 4724-4729, vol. 97, No. 9.
Detlev Buttgereit et al., “Growth-Dependent Regulation of rRNA Synthesis is Mediated by a Transcription Initiation Factor (TIF-IA)”, Nucleic Acids Research, 1985, pp. 8165-8179, vol. 13, No. 22, IRL Press Limited, Oxford, England.
Robert T. Yamamoto et al., “RRN3 Gene ofSaccharomyces cerevisiaeEncodes an Essential RNA Polymerase I Transcription Factor Which Interacts With The Polymerase Independently of DNA Template”, The EMBO Journal, 1996, pp. 3964-3973, vol. 15, No. 15, Oxford University Press.
Grummt Ingrid
Vingron Martin
Deutsches Krebsforschungszentrum Stiftung des Oeffentlichen Rech
Garvey Tara L.
Heller Ehrman LLP
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