RNA oligonucleotides that bind HIV tat protein

Details RNA oligonucleotides that bind HIV tat protein RNA oligonucleotides that bind HIV tat protein

1995-10-10

1998-10-13

Railey, II, Johnny F.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

536 231, 514 44, C12Q 168, C07H 2102

Patent

active

058210466

ABSTRACT:
A synthetic molecule comprising an RNA binding sequence or sequences corresponding to the site bound by the HIV protein tat and capable of binding to tat within cells. The binding sequence or sequences, by binding tat within cells, can act to cause inhibition of growth of any HIV present in the cells, and so has potential therapeutic use in treatment of patients affected with HIV. The invention also provides an assay for identifying compounds that inhibit tat binding.

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