Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2008-09-09
2008-09-09
McGarry, Sean (Department: 1635)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C536S024500
Reexamination Certificate
active
10680449
ABSTRACT:
The present invention provides novel methods for manipulating levels of expression of gene products using RNA interference (RNAi). The methods disclosed can be used to investigate gene function, to create disease-resistant organisms, and to treat disease.
REFERENCES:
patent: 6544790 (2003-04-01), Sabatini
patent: 2003/0036197 (2003-02-01), Glassman et al.
patent: 2003/0068821 (2003-04-01), Lois-Caballe et al.
patent: 2003/0139363 (2003-07-01), Kay et al.
patent: 2003/0143597 (2003-07-01), Finney et al.
patent: 2003/0144232 (2003-07-01), Agami et al.
patent: 2003/0144239 (2003-07-01), Agami et al.
patent: 2003/0150017 (2003-08-01), Mesa et al.
patent: 2003/0167490 (2003-09-01), Hunter et al.
patent: 2003/0224432 (2003-12-01), Myers et al.
patent: 2004/0029275 (2004-02-01), Brown et al.
patent: 2004/0203145 (2004-10-01), Zamore et al.
patent: 2004/0224405 (2004-11-01), Leake et al.
patent: 2004/0259247 (2004-12-01), Tuschi et al.
Hirashima et al. (1986) PNAS 83:7726-7730.
Cox et al. (1998) Genes & Development 12:3715-3727.
Holen et al. [2002] Nucleic Acids Res. 30:1757-1766.
Sijen et al. (2001) Cell 107:465-476.
Fire et al. (1990) Gene 93:189-198.
Kennerdell et al. (1998) Cell 95:1017-1026.
Elbashir et al. (2001) Nature 411:494-498.
Pal-Bhadra et al. (1998) Cell 99: 35-46.
Voinnet et al. (1998) Cell 95:177-187.
Barr, 1998, Nature Genetics 19:121-124.
Reddy et al., 1999 TINS 22:248-255.
Mullins et al. (1996) J. Clin. Invest. 98(11), Supplement S37-S40.
Bradley et al. (1992) Biotechnology 10: 534-539.
Doetschmann (1999) Lab. Animal Sci., vol. 49 (2), 137-143.
Moens et al. (1993) Development, vol. 199, 485-499.
Jacks et al. (1992) Nature, vol. 359, 295-300.
Hannon, 2002, Nature 418:244-251.
Alder et al., “Gene Silencing inCaenorhabditis elegansby transitive RNA interference,”RNA, 2003, 9:25-32.
Bargmann, “High Throughput Reverse Genetics: RNAi Screen inCaenorhabditis elegans,”Genome Biology, Jan. 31, 2001, 2(2):reviews 1005.1-1005.3.
Boutla et al., “Induction of RNA interference inCaenorhabditis elegansby RNAs derived from plants exhibiting post-transcriptional gene silencing,”Nucleic Acids Research, Feb. 4, 2002, 30(7):1688-1694.
Brown et al., “Stable and heritable gene silencing in the malaria vectorAnopheles stephensi,” Nucleic Acids Research, Jun. 13, 2003, 31(150:e85.
Chi et al., “Genomewide view of gene silencing by small interfering RNAs,” PNAS, May 27, 2003, 100(11):6343-6346.
Chicas et al., “Characteristics of post-transcriptional gene silencing,”EMBO reports, Sep. 28, 2001, 2(11):992-996.
Chuang et al., “Specific and heritable genetic interference by double-stranded RNA inArabidopsis thaliana,” PNAS, Apr. 25, 2000, 97(9):4985-4990.
Cottrell et al., “Silence of the strands: RNA interference in eukaryotic pathogens,”Trends in Microbiology, Jan. 2003, 11(1):37-43.
Dillin, “The specifics of small interfering RNA specificity,”PNAS, May 27, 2003, 100(11):6289-6291.
Feinburg et al., “Transport of dsRNA into Cells by Transmembrane Protein SID-1,”Science, Sep. 12, 2003, 301:1545-47.
Fire at al., “Potent and specific genetic interference by double-stranded RNA inCaenorhabditis elegans,” Nature, Feb. 19, 1998, 391:806-811.
Firon et al., “Identifying essential genes in fungal pathogens of humans,”Trends in Microbiology, Oct. 2002, 10(10):456-62.
Hamilton et al., “Two classes short interfering RNA in RNA silencing,”EMBO, Jul. 16, 2002, 21(17):4671-4679.
Hammond et al., “Post-transcriptional gene silencing by double stranded RNA,”Nature, Feb. 2001; 2:110-117.
Hannon, “RNA interference,”Nature, Jul. 11, 2002, 418:244-251.
Heidencreich et al., “AML1/MTG8 oncogene suppression by small interfering RNAs supports myeloid differentiation of t(8;21)-positive leukemic cells,”Blood, Apr. 15, 2003, 101(8):3157-3163.
Himber et al., “Transitivity-dependent and -independent cell-to-cell movement of RNA silencing,”EMBO, Jul. 10, 2003, 22(17):4523-4533.
Jorgensen, “RNA traffics information systematically in plants,”PNAS, Sep. 3, 2002, 99(18):11561-11563.
Kamath et al., “Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA inCaenorhabditis elegans,” Genome Biology, 2000, 2(1):research0002.1-0002.9.
Klahre et al., “High molecular weight RNAs and small interfering RNAs induce systemic posttranscriptional gene silencing in plants,”PNAS, Sep. 3, 2002, 99(18):11981-11986.
Lipardi et al., “RNAi as Random Degradative PCR: siRNA Primers Convert mRNA into dsRNAs that Are Degraded to Generate New siRNAs,”Cell, Nov. 2, 2001, 107:297-307.
Malhotra et al., “Double-stranded RNA-mediated gene silencing of cysteine proteases (falcipain-1 and -2) ofPlasmodium falciparum,” Molecular Microbiology, 2002, 45(5):1245-1254.
Mangeot et al., “A universal transgene silencing method based on RNA interference,”Nucleic Acids Research, 2004, 32(12):e102 (6 pages).
Martens et al., “RNAi inDictyostelium: The Role of RNA-directed RNA Polymerases and Double-stranded RNase,”Molecular Biology of the Cell, Feb. 2002, 13:445-453.
Ngo et al., “Double-stranded RNA induces mRNA degradation inTrypanosoma brucei,” Proc Natl Acad Sci., Dec. 1998, 95:14687-14692.
Nishikura, “A Short Primer on RNAi: RNA-Directed RNA Polymerase Acts as a Key Catalyst,”Cell, Nov. 16, 2001, 107:415-418.
Pandolfini et al., “Expression of self-complementary hairpin RNA under the control of the rolC promoter confers systemic disease resistance to plum pox virus without preventing local infection,”BMC Biotechnology, Jun. 25, 2003, 3:1-15.
Roignant et al., “Absence of transitive and systemic pathways allows cell-specific and isoform-specific RNAi inDrosophila,” RNA, 2003, 9(3):299-308.
Schultheiss et al., “A Small GTP-Binding Host Protein Is Required for Entry of Powdery Mildew Fungus into Epidermal Cells of Barley,”Plant Physiology, Apr. 2002, 128(4):1447-1454.
Schwarz et al., “Evidence that siRNAs Function as Guides, Not Primers, in theDrosophilaand Human RNAi Pathways,”Molecular Cell, Sep. 2002, 10:537-548.
Shuey et al., “RNAi: gene-silencing in therapeutic intervention,”Drug Discovery Today, Oct. 2002, 7(20):1040-1046.
Sijen et al., “On the role of RNA Amplification in dsRNA-Triggered Gene Silencing,”Cell, Nov. 16, 2001, 107:465-476.
Tang et al., “A biochemical framework for RNA silencing in plants,”Gene&Development, Nov. 14, 2002, 17:49-63.
Tuschul et al., “Targeted mRNA degradation by double-stranded RNA in vitro,”Genes&Development, Oct. 28, 1999, 13:3191-3197.
Vaistij et al., “Spreading of RNA Targeting and DNA Methylation in RNA Silencing Requires Transcription of the Target Gene and a Putative RNA-Dependent RNA Polymerase,”The Plant Cell, Apr. 2002, 14:857-867.
Valdes et al., “Using Double-stranded RNA to Prevent in Vitro and in Vivo Viral Infections by RecombinantBaculovirus,” Journal of Biological Chemistry, May 23, 2003, 278(21):19317-19324.
Van Houdt et al., “RNA Target Sequences Promote Spreading of RNA Silencing,”Plant Physiology, Jan. 2003, 131:245-253.
Vanitharani et al., “Short interfering RNA-mediated interference of gene expression and viral DNA accumulation in cultured plant cells,”PNAS, Aug. 5, 2003, 100(16):9632-9636.
Vaucheret et al., “Post-transcriptional gene silencing in plants,”Journal of Cell Science, 2001, 114:3083-3091.
Wagner et al., “Double-stranded RNA poses puzzle,”Nature, Feb. 19, 1998, 391:744-745.
Waterhouse et al., “Exploring Plant Genomes by RNA-induced Gene Silencing,”Nature Reviews Genetics, Jan. 2003; 4:29-37.
Wesley et al., “Construct design for efficient, effective and high-throughput gene silencing in plan
Huang Liwen
Ley, III Herbert L.
Ley, III Herbert L.
McGarry Sean
Myriad Genetics Inc.
Myriad IP Department
Wollenberger Louis
LandOfFree
RNA interference using a universal target does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with RNA interference using a universal target, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and RNA interference using a universal target will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3916607