RNA interference induction element and use thereof

Details RNA interference induction element and use thereof RNA interference induction element and use thereof

2006-05-15

2010-12-07

Whiteman, Brian (Department: 1635)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C514S04400A

Reexamination Certificate

active

07847089

ABSTRACT:
The present invention provides an RNA interference induction element containing a nucleotide sequence selected from among the nucleotide sequences (a) to (c) below: (a) a nucleotide sequence containing SEQ ID NO:1 or a sequence complementary thereto; (b) a nucleotide sequence containing at least 15 continuous nucleotides present in the nucleotide sequence (a) above, and possessing RNA interference induction potential; (c) a nucleotide sequence having a homology of at least 70% to any one of the nucleotide sequences (a) and (b) above, and possessing RNA interference induction potential. Using the RNA interference induction element of the present invention, it is easily possible to knock down a desired target gene, and to produce a siRNA for a desired target gene.

REFERENCES:
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R. A. Martienssen et al., “RNA Interference and Heterochromatin in the Fission YeastSchizosaccharomyces pombe”, TRENDS in Genetics, vol. 21, No. 8, pp. 450-456, Aug. 2005.
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