Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Patent
1997-09-18
2000-10-24
McKelvey, Terry
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
435243, 4353201, 435410, 536 241, C12N 510, C12N 100, C12N 1511, C12N 1563
Patent
active
061365971
ABSTRACT:
A cis-acting posttranscriptional regulatory element (PRE) useful for efficient RNA export of RNA is provided. The element termed WPRE, is originally derived from woodchuck hepatitis virus. The invention also provides a method for enhancing the expression of transgenes by insertion of the WPRE nucleic acid sequences in operably linkage with the transgene.
REFERENCES:
patent: 5585263 (1996-12-01), Hammarskjold et al.
patent: 5637463 (1997-06-01), Dalton et al.
Huang et al., "Cellular Proteins Than Bind to the Hepatitis B Virus Posttranscriptional Regulatory Element", Virology, 1996, vol. 217, pp. 573-581.
Heapy et al., "HIV-1 Regulatory of Virion Expression (Rev) Protein Binds to an RNA Stem-Loop Structure Located within the Rev Response Element Region," cell, Feb. 23, 1990, vol. 342, pp. 686-687.
Zapp et al. "Sequence-Specific RNA Binding by the HIV-1 Rev Protein," Nature, Dec. 7, 1989, vol. 342, pp. 714-716.
Galibert et al., "Nucleotide Sequence of a Cloned Woodchuck Hepatitis Virus Genome:Comparision with the Hepatitis B Virus Sequence," Journal of Virology, Jan. 1982, vol. 41, No. 1, pp. 51-65.
Donello John Edward
Hope Thomas J.
Trono Didier
Zufferey Romain
Haile Lisa A.
McKelvey Terry
The Salk Institute for Biological Studies
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