RNA editing enzyme and methods of use thereof

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4353201, 435348, 435325, 435369, 435358, 435365, 435357, 536 232, 536 235, 536 2431, C12N 978, C12N 1555, C12N 1585

Patent

active

056437781

ABSTRACT:
The present invention provides novel human polynucleotide sequences and the recombinant human double-stranded RNA adenosine deaminase enzyme (DRADA) proteins encoded thereby and methods of use thereof.

REFERENCES:
patent: 4419446 (1983-12-01), Howley et al.
patent: 4822736 (1989-04-01), Kellems et al.
patent: 5004810 (1991-04-01), Draper
Hough et al, "The Double-Stranded RNA Adenosine Deaminase" J. Cell. Biochem. Suppl. 18C: 130 (Feb. 19, 1994).
Hough et al, "Purification of the Xenopus laeuis Double-stranded RNA Adenosine Deaminase", J. Biol. Chem. 269(13):9933-9939 (Apr. 1994).
G-S. Feng et al, "Identification of Double-Stranded RNA-binding Domains in the Interferon-induced Double-stranded RNA-activated p68 Kinase", Proc. Natl. Acad. Sci. USA, 89:5447-5451 (Jun., 1992).
E. Meurs et al, "Molecular Cloning and Characterization of the Human Double-Stranded RNA-Activated Protein Kinase Induced by Interferon", Cell, 62:379-390 (Jul. 27, 1990).
B. Bass et al, "An Unwinding Activity that Covalently Modifies its Double-Stranded RNA Substrate", Cell, 55:1089-1098 (Dec. 23, 1988).
B. Bass et al, "A Developmentally Regulated Activity that Unwinds RNA Duplexes", Cell, 48:607-613 (Feb. 27, 1987).
B. Bass et al, "Biased Hypermutation of Viral RNA Genomes Could be Due to Unwinding/Modification of Double-Stranded RNA", Cell, 56:331 (Feb. 10, 1989).
R. Wagner et al, "A Double-Stranded RNA Unwinding Activity Introduces Structural Alterations by Means of Adenosine to Inosine Conversions in Mammalian Cells and Xenopus Eggs", Proc. Natl. Acad. Sci. USA, 86:2647-2651 (Apr. 1989).
R. Wagner et al, "Cell Cycle Expression of RNA Duplex Unwindase Activity in Mammalian Cells", Mol. Cell Biol., 8(2):770-777 (Feb. 1988).
R. Wagner et al, "Double-Stranded RNA Unwinding and Modifying Activity is Detected Ubiquitously in Primary Tissues and Cell Lines", Mol. Cell Biol., 10(10):5586-5590 (Oct. 1990).
R. Wagner et al, "Expression of an RNA Duplex Unwindase Activity in Mammalian Cells" Current Communications in Molecular Biology/Antisense RNA and DNA, D.A. Melton, ed., Cold Spring Harbor Laboratory Press, pp. 103-109 (May 1988).
M. Rebagliati et al, "Antisense RNA Injections in Fertilized Frog Eggs Reveal an RNA Duplex Unwinding Activity", Cell, 48:599-605 (Feb. 27, 1987).
Y. Skeiky et al, "Developmental Regulation of Covalent Modification of Double-Stranded RNA During Silkmoth Oogene-sis", J. Mol. Biol., 218:517-527 (Apr. 5, 1991).
A. Polson et al, "The Mechanism of Adenosine to Inosine Conversion by the Double-Stranded RNA Unwinding/Modifying Activity: A High-Performance Liquid Chromatography-Mass Spectrometry Analysis", Biochem., 30:11507-11514 (Dec. 10, 1991).
K. Nishikura et al, "Substrate Specificity of the dsRNA Unwinding/Modifying Activity", EMBO J., 10(11):3523-3532 (Oct. 11, 1991).
K. Nishikura et al, "Modulation of Double-Stranded RNAs in vivo by RNA Duplex Unwindase" Annals of the New York Acad. of Sci., 660:240-250 (Oct. 28, 1992).
K. Nishikura, "A Cellular Activity that Modifies and Alters the Structure of Double-Stranded RNA" Gene Regulation: Biology of Antisense RNA and DNA, R.P. Erickson and J.G. Izant, Raven Press Ltd., NY, pp. 21-34 (Dec. 11, 1991).
D. Kimelman et al. "An Antisense mRNA Directs the Covalent Modification of the Transcript Encoding Fibroblast Growth Factor in Xenopus Oocytes", Cell, 59:687-696 (Nov. 17, 1989).
R. Cattaneo et al, "Biased Hypermutation and Other Genetic Changes in Defective Measles Viruses in Human Brain Infections", Cell, 55:255-265 (Oct. 21, 1988).
L. Sharmeen et al, "Tat-dependent Adenosine-to-Inosine Modification of Wild-type Transactivation Response RNA", Proc. Natl. Acad. Sci. USA, 88:8096-8100 (Sep. 1991).
U. Kim et al, "Double-Stranded RNA Adenosine Deaminase: A Potential Agent for RNA Editing?" in RNA Editing, R. Benne, Ed. (Simon and Schuster Intnl., Chichester, England, pp. 179-192 (July 1993).
U. Kim et al, "Double-Stranded RNA Adenosine Deaminase as a Potential Mammalian RNA Editing Factor", Cell Biology, 4:285-293 (Aug. 19, 1993).
U. Kim et al, "Purification and Characterization of Double-stranded RNA Adenosine Deaminease from Bovine Nuclear Extracts" J. Biol. Chem., 269(18):13480-13489 (May 6, 1994).
B. Sommer et al, "RNA Editing in Brain Controls a Determinant of Ion Flow in Glutamate-Gated Channels", Cell, 67:11-19 (Oct. 4, 1991).
T. Verdoorn et al, "Structural Determinants of Ion Flow Through Recombinant Glutamate Receptor Channels", Science, 252:1715-718 (Jun. 21, 1991).
M. Kohler et al, "Determinants of Ca.sub.2 + Permeability in Both TM1 and TM2 of High Affinity Kainate Receptor Channels: Diversity by RNA Editing", Neuron, 10:491-500 (Mar. 1993).
M. Higuchi et al, "RNA Editing of AMPA Receptor Subunit GluR-B: A Base-Paired Intron Exon Structure Determines Position and Efficiency", Cell, 75(7):1361-1370 (Dec. 31, 1993).
S. Rataul et al, "Irreversible Modification of Measles Virus RNA in Virtro by Nuclear RNA-Unwinding Activity in Human Neuroblastoma Cells", J. Virol., 66 (3):1769-1773 (Mar. 1992).
J. Thakkar et al, "Isolation and Characterization of AMP Deaminase from Mammalian (Rabbit) Myocardium", Biochem. J., 290:335-341 (Mar. 1, 1993).
C. Yang et al, "Cloning and Nucleotide Sequence of the Escherichia coli Cytidine Deaminase (ccd) Gene", Biochemistry, 31:4168-4174 (May 5, 1992).
D. Wilson et al, "Atomic Structure of Adenosine Deaminase Complexed with a Transiton-State Analog: Understanding Catalysis and Immunodeficiency Mutations", Science, 252:1278-1284 (May 31, 1991).
G. Cesareni, "Peptide Display on Filamentous Phage Capsids--A New Powerful Tool to Study Protein-Ligand Interaction", FEBS Letters, 307(1):66-70 (Jul. 1992).
H. Gram et al, "Phage Display as a Rapid Gene Expression System: Production of Bioactive Cytokine-Phage and Generation of Neutralizing Monoclonal Antibodies", J. Immunol. Methods, 161:169-176 (May 27, 1993).
J. Grinspan et al, "Bovine Endothelial Cells Transformed in Vitro by Benzo(a)pyrene", J. Cell Physiol., 114:328-338 (1983).
A. Gatignol et al, "Relatedness of an RNA-Binding Motif in Human Immunodeficiency Virus Type 1 TAR RNA-Binding Protein TRBP to Human P1/dsI Kinase and Drosophila Staufen", Mol. Cell. Biol, 13 (4):2193-2202 (Apr. 1993).
D. St. Johnson et al, "A Conserved Double-Stranded RNA-Binding Domain", Proc. Natl. Acad. Sci. USA, 89:10979-10983 (Nov. 1992).
D. Miller et al, "An Insect Baculovirus Host-Vector System for High-Level Expression of Foreign Genes", Genetic Engineering, 8:277-298 (May 1986).
M. Gething et al, "Cell-Surface Expression of Influenza Haemagglutinin from a Cloned DNA Copy of the RNA Gene", Nature, 293:620-625 (Oct. 1981).
R. Kaufman et al, "Coamplification and Coexpression of Human Tissue-Type Plasminogen Activator and Murine Dihydrofolate Reductase Sequences in Chinese Hamster Ovary Cells", Mol. Cell Biol., 5(7):1750-1759 (Jul. 1985).
C. Swimmer et al, "Phage Display of Ricin B Chain and its Single Binding Domains: System for Screening Galactose-Binding Mutants", Proc. Natl. Acad. Sci. USA, 89:3756-3760 (May 1992).
J. Dignam et al, "Accurate Transcription Initiation by RNA Polymerase II in a Soluble Extract from Isolated Mammalian Nuclei", Nucleic Acids Res., 11(5):1475-1489 (Mar. 1983).
M. SilberKlang et al, "Use of in Vitro .sup.32 P Labeling in the Sequence Analysis of Nonradioactive tRNAs", Methods Enzymol., 59:58-109 (Apr. 28, 1978).
C. Lee et al, "cDNA Cloning Using Degenerate Primers", in PCR Protocols: A Guide to Methods and Application, M. A. Innis et al, Eds., Academic Press, Inc., San Diego, CA, pp. 46-53 (Dec. 28, 1989).
M. Kozak, "The Scanning Model for Translation: An Update", J. Cell Biol., 108:229-241 (Feb. 14, 1989).
J. Devereux et al, "A Comprehensive Set of Sequence Analysis Programs for the VAX", Nucleic Acids Res., 12(1):387-395 (Jan. 1984).
S. Haynes, "Research Review: The RNP Motif Protein Family", New Biol., 4(5):421-429 (May 1992).
Z. Chang et al, "Deduced Amino Acid Sequence of Escherichia coli Adenosine Deaminase Reveals Evolutionarily Conserved Amino Acid Residues: Implications for Catalytic Function", Biochem., 30:2273-2280 (Feb. 26, 1991).
B. Teng et

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

RNA editing enzyme and methods of use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with RNA editing enzyme and methods of use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and RNA editing enzyme and methods of use thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-596148

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.