RNA aptamers and the uses thereof

Details RNA aptamers and the uses thereof RNA aptamers and the uses thereof

2011-08-16

2011-08-16

Schnizer, Richard (Department: 1635)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S320100

Reexamination Certificate

active

07999089

ABSTRACT:
The present invention relates to RNA aptamers and uses thereof, more precisely RNA aptamers interfering the interaction of TCF with other proteins by binding specifically to β-catenin, RNA aptamers binding specifically to HMG domains of TCF-I proteins and uses of the same. The RNA aptamer of the present invention can be effectively used for the development of an anticancer agent since it binds specifically to TCF-I to interrupt the interaction of TCF with β-catenin involved in tumorigenesis and metastasis and the transcriptional activity of TCF-I in relation to oncogenes.

REFERENCES:
patent: 2006/0252045 (2006-11-01), Chatterjee-Kishore et al.
Park, M.W. et al. : “Inhibition of the DNA binding by the TCF-1 binding RNA aptamer” Biochemical and biophysical research communications (Biochem. biophys. res. commun.) Biochemical and biophysical research communications, vol. 330, pp. 11-17 (Apr. 29, 2005).
Tuerk, C. et al.: Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science, vol. 249(4968), pp. 505-510 (Aug. 3, 1990).
Famulok, M. et al. : “Intramers as promising new tools in functional proteomics.” Chmistry & Biology, vol. 8 (10), pp. 931-939 (Oct. 2001).
Cassiday, L.A. et al. : “In Vivo Recognition of an RNA Aptamer by Its Transcription Factor Target” Biochemistry, vol. 40(8), pp. 2433-2438 (Feb. 27, 2001).

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