Ring substituted pyrazino-isoquinoline derivatives and their pre

Details Ring substituted pyrazino-isoquinoline derivatives and their pre Ring substituted pyrazino-isoquinoline derivatives and their pre

1978-08-07

1979-07-24

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544344, A61K 31495, C07D40502, C07D40102

Patent

active

041623193

ABSTRACT:
Isoquinolines of the formula ##STR1## wherein R.sup.1 is H, OH, alkyl; R.sup.2 is H, or an unsubstituted or substituted carbonyl, carbonyloxy or thiocarbonyl group; R.sup.3 is H, alkyl or hydroxy alkyl; R.sup.4 is H, alkyl or phenyl; R.sup.5 is O, H,H or H and alkyl, phenyl, halo or hydroxy; R.sup.6 and R.sup.7 are optional substituents; and R.sup.8 is H or alkyl, R.sup.2 being a thiocarbonyl or carbonyloxy group when R.sup.1 and R.sup.3 to R.sup.8 are H and X is O; and their physiologically acceptable salts, are antihelmintics, especially against cestodes and trematodes; some also possessing CNS activity, e.g., psychotropic and blood pressure regulating activity.

REFERENCES:
patent: 4001411 (1977-01-01), Seubert et al.
patent: 4049659 (1977-09-01), Pohlke

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