Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes and pha

Details Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes and pha Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes and pha

1993-04-16

1994-02-15

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514432, 514456, 514481, 514617, 514619, 514629, 514648, 514654, 514655, 549 23, 549404, 560 28, 564163, 564168, 564184, 564211, 564328, 564374, 564384, 564389, 564428, A61K 31165, C07C21142

Patent

active

052867536

ABSTRACT:
The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes, 3-aminochromanes, and 3-aminothiochromanes, including their corresponding sulfoxides and sulfones, which ring-substituted compounds exhibit agonist activity at the serotonin 1A receptor.

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Holz, W. et al, ".alpha.-Adrenergic Agents. 3. Behavioral Effects of 2-Aminotetralins", Psychopharmacology (1982) vol. 77, 259-267.
Kline, T. et al, CA. vol. 12, 118413w 1990.
Glennon, J. Med. Chem., 30, 1-12 (1987).

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