Ring-opening process for preparing azetidinone intermediates

Details Ring-opening process for preparing azetidinone intermediates Ring-opening process for preparing azetidinone intermediates

1986-01-13

1988-09-13

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540357, C07D20508, C07B 4506, C07F 718

Patent

active

047711345

ABSTRACT:
Compounds of formula I ##STR1## wherein R.sub.1 and R.sub.2 is each H, halo or an organic group, R.sub.3 is H or organic group, n=1 or 2, M is a heavy mono- or divalent metal, or M.sub.2 A wherein M.sub.2 is a heavy divalent metal and A is an organic or inorganic group, are prepared by treating a starting penicillin in a solvent with a salt of M.sub.1 or M.sub.2 A in the presence of a base at a temperature of from -70.degree. to 100.degree. C.

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