Ring open nucleoside analogues

Details Ring open nucleoside analogues Ring open nucleoside analogues

1980-09-16

1982-08-31

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

544298, 544309, 544313, 544277, 536 23, 536 24, 536 26, 424251, 424253, C07D47318, C07D47334

Patent

active

043473601

ABSTRACT:
Nucleoside analogues having a ring-open structure, of general formula: ##STR1## where R and R' may be hydrogen, silyl groups, substituted alkyl groups and the like, and B is a base such as adenine, have been shown to exhibit anti-viral and other biological activities at non-toxic levels. Also provided are phosphate-linked dinucleotide compounds of similar structures.

REFERENCES:
patent: 4158056 (1979-06-01), Nagarajan
patent: 4199574 (1980-04-01), Schaeffer
Bryant et al., J. Org. Chem., 44, (21), 3733, 1979.
Gillen, M. F., Dissertation Abst. International, vol. 41, No, 8, Feb. 1981.
Gillen, M. F., "Synthesis and Properties of Novel Nucleoside and Nucleotide Analogues", pp. 1-83, Apr. 1980.
Ogilive, et al., Tetrahedron Letters, vol. 21, pp. 327-330, 1980.

Affiliated with

Also associated with

Rating

Ring open nucleoside analogues does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ring open nucleoside analogues, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ring open nucleoside analogues will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2185096