Ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives as benzodia

Details Ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives as benzodia Ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives as benzodia

1985-06-19

1986-07-22

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

2602444, 514256, 514273, 514275, 514293, 544310, 544317, 544320, 544321, 544322, 544327, 544328, 544331, 546 82, 546 83, A61K 3155, C07D47104, C07D47114

Patent

active

046020144

ABSTRACT:
Compounds of the formula formula IA or IB ##STR1## wherein A represents an optionally substituted saturated divalent grouping which together with the two carbon atoms to which it is attached represents a fused 5-, 6- or 7-membered carbocyclic or heterocyclic ring selected from optionally substituted fused cyclopenteno, cyclohexeno, cyclohepteno, dihydrothieno, dihydrothiopyrano, tetrahydrothiepino, dihydrofuro, dihydropyrano, tetrahydrooxepino, dihydropyrrolo, tetrahydropyrido and tetrahydroazepino; R.sub.1 represents lower alkyl, phenyl, or phenyl mono- or disubstituted by lower alkyl, lower alkoxy, halogen or trifluoromethyl; or R.sub.1 represents an aromatic heterocyclic radical selected from e.g. optionally substituted pyridyl, quinolyl, isoquinolyl, pyrimidyl and thiazolyl; R.sub.2, R.sub.3, R.sub.3 ' are hydrogen or lower alkyl; and pharmaceutically acceptable salts; are useful as benzodiazepine receptor modulators for the treatment of nervous system disorders. Pharmaceutical compositions, methods of preparation and certain intermediates useful as benzodiazepine receptor modulators are also disclosed.

REFERENCES:
patent: 3992540 (1976-11-01), Clemence et al.
patent: 4107310 (1978-08-01), Allais et al.
patent: 4312870 (1982-01-01), Yokoyama
patent: 4450166 (1984-05-01), Clemence et al.
patent: 4450167 (1984-05-01), Martret et al.
patent: 4459298 (1984-07-01), Bernard
patent: 4468400 (1984-08-01), Gold et al.
patent: 4479955 (1984-10-01), Yokoyama
patent: 4524146 (1985-06-01), Yokoyama
Khan et al., J. Het. Chem., 20, 475 (1983).
Kumar et al., J. Chem. Soc., Perkin I, 857 (1978).
Titkona et al., Khim.-Farm. Zh., 16, 699 (1982) Abstract only.
Kilbourn et al., J. Org. Chem., 37, 1145 (1972).
C. A. Boast et al., Neuropharmacology, 22, 1511-1521 (1983).
C. A. Boast et al., Pharmacology, Biochemistry and Behavior 23, pp. 639-644 (1985).
P. L. Wood et al., J. Pharmacology and Experimental Therapeutics, 231, 572-576 (1984).

Affiliated with

Also associated with

Rating

Ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives as benzodia does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives as benzodia, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives as benzodia will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-866215